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anti-Mouse (Murine) CD51 Antikörper:
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Human Monoclonal CD51 Primary Antibody für BR, CyTOF - ABIN5012935
Cabezón, Sintes, Llinàs, Benitez-Ribas: Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. in Immunology letters 2010
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Mouse (Murine) Monoclonal CD51 Primary Antibody für BR, FACS - ABIN1176967
Roberts, Yokoyama, Kehn, Shevach: The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells. in The Journal of experimental medicine 1991
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Mouse (Murine) Monoclonal CD51 Primary Antibody für BR, FACS - ABIN1176957
Bader, Rayburn, Crowley, Hynes: Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. in Cell 1998
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Mouse (Murine) Monoclonal CD51 Primary Antibody für FACS - ABIN2689325
Frieser, Hallmann, Johansson, Vestweber, Goodman, Sorokin: Mouse polymorphonuclear granulocyte binding to extracellular matrix molecules involves beta 1 integrins. in European journal of immunology 1997
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Mouse (Murine) Monoclonal CD51 Primary Antibody für BR, FACS - ABIN2689326
Nakamura, Pilkington, Lakkakorpi, Lipfert, Sims, Dixon, Rodan, Duong: Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone. in Journal of cell science 2000
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Human Monoclonal CD51 Primary Antibody für CyTOF, FACS - ABIN4900797
Cornick, Moreau, Chadee: Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin. in PLoS pathogens 2016
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Human Monoclonal CD51 Primary Antibody für IHC (fro), FACS - ABIN1042463
de Vries, Keizer, te Velde, Voordouw, Ruiter, Rümke, Spits, Figdor: Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells. in International journal of cancer. Journal international du cancer 1986
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Human Polyclonal CD51 Primary Antibody für CyTOF, FACS - ABIN4900194
Rhein, Brouillette, Schaack, Chiorini, Maury: Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry. in Journal of virology 2016
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Human Polyclonal CD51 Primary Antibody für WB - ABIN2801895
Suzuki, Argraves, Arai, Languino, Pierschbacher, Ruoslahti: Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. in The Journal of biological chemistry 1987
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Human Polyclonal CD51 Primary Antibody für IHC - ABIN966421
Suzuki, Argraves, Pytela, Arai, Krusius, Pierschbacher, Ruoslahti: cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. in Proceedings of the National Academy of Sciences of the United States of America 1986
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The results of this study indicated that alphavbeta5 integrin, as the very receptor of Vitronectin, is responsible for the progress of the initial differentiation stage in mouse cerebellar granule cellss
alphav deficiency did not impact on the capacity of Treg to suppress proliferation of naive conventional T cells in vitro as well as in vivo
Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis
Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction.
These results demonstrate that OPN expressed by fatigue-resistant/slow motor neurons is involved in the second-wave neurodegeneration by up-regulating MMP-9 through alphavbeta3 integrin in the mouse model of amyotrophic lateral sclerosis.
Angiogenic activity in the atherosclerotic plaques coincides with alphavbeta3-integrin by the adventitial vasa vasorum and intraplaque neovascularization.
Tat PTD-Endostatin-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat PTD-Endostatin-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.
The synergy of circulating factor suPAR and APOL1 G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM.
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
the present results suggest that CS-E is capable of inhibiting OA-induced osteoclast differentiation by blocking the interaction of OA to integrin a5b3 and heparan sulfate proteoglycan .
These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1.
identify alphavbeta3 as the primary integrin heterodimer mediating shear stress-induced proinflammatory responses and as a key contributor to early atherogenic inflammation
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.
Therapeutic delivery of alphavbeta1 inhibitor attenuated bleomycin-induced pulmonary fibrosis and carbon tetrachloride-induced liver fibrosis.
alphaVbeta6 integrin-deficiency results in periodontal pathogens invading gingiva and aortic adventitia and eliciting inflammasome activation.
These results suggest that phloretin was an inhibitor of actin podosomes and sealing zone, disrupting alpha5beta3 integrin-c-Src-Pyk2/Syk signaling pathway for the regulation of actin cytoskeletal organization in osteoclasts.
TN-C may enhance inflammatory responses by accelerating macrophage migration and synthesis of proinflammatory/profibrotic cytokines via integrin alphaVbeta3/FAK-Src/NF-kappaB, resulting in increased fibrosis.
Lung histology revealed aberrant elastin production and impaired lung septation in oxygen-exposed lungs, while tropoelastin, integrin alphav, fibulin-1, fibulin-2 and fibulin-4 gene expression were elevated.
ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells.
SAA1 in combination with integrin alphaV and beta3 can serve as an indicator of high glioblastoma risk.
Findings indicated that IL-32gamma suppressed skin carcinogenesis through the inhibition of both stemness and the inflammatory tumor microenvironment by the downregulation of TIMP-1 and ITGAV via inactivation of NF-kappaB signaling.
This study provides evidence that germline polymorphisms in VEGFR1, KRAS and ITGAV genes are associated with prognosis in stages II-III colon cancer patients. As stage and tumor location are correlated with prognosis, future genetic studies should stratify colon cancer patients according to these parameters.
Binding of small molecule ligands and radiolabelled RGD peptides is modulated by expression and activation status of alphavbeta3 integrin.
There is no difference in the expression of Integrin alphavbeta3 between tumor samples from glioblastomas patients with methylated or unmethylated promoter regions in the (6)O-methylguanine methyltransferase (MGMT). Further analysis of the integrin subunits via ELISA from histologic sections revealed that there is no difference in integrin subunit expression between these patients.
These data suggested CD51 was a predictor for the prognosis of esophageal squamous cell carcinoma patients
This study shows that the D2A sequence of the UPAR induces cell growth through alphaVbeta3 integrin and EGFR.
Cyclin D1b markedly amplified integrin alphavbeta3 expression, which was further up-regulated under lipopolysaccharide stimulation.
differential expression of alphavbeta3 and alphavbeta6 was examined in MDA-MB-231, MDA-MB-468 and MCF-10A cells, which signify three different stages of breast cancer development from highly metastatic to non-tumorigenic stage.
High expression of Integrin alphaVbeta6 is an important cause of active proliferation and impaired apoptosis in cervical cancer.
The results of the present study suggest that the traditional Chinese formula WD3 may inhibit gastric tumor growth, potentially via the downregulation of integrin alphav beta3 and the inhibition of ERK1/2 phosphorylation in vivo
of AIM-cleavage and resulting functional modification could be the basis for designing safe and efficient AIM therapy for various diseases
show that sCD40L/alpha5beta1 interaction leads to platelet activation as evaluated in the human whole blood
Among Greek and Polish patients with intracerebral hemorrhage, the rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in a codominant model of inheritance.
Although Mn(2+) potently activates other integrins and increases affinity of alphaVbeta6 for pro-TGF-beta1 25- to 55-fold, it increases alphaVbeta8 affinity only 2- to 3-fold.
This work identifies that therapeutic targeting of integrins containing an alpha V integrin unit inhibits cancer progression and thus may be of clinical benefit.
this study uncovers a novel pathway by which the TGFbeta-activating integrin alphavbeta8 is expressed in the human intestine on dendritic cell subsets, which is upregulated in patients with inflammatory bowel disease
Integrin alphavbeta3 has a role in enhancing beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations
BKCa has a role in promoting growth and metastasis of prostate cancer through facilitating the coupling between alphavbeta3 integrin and FAK
Blocking ligand binding to the alphaVbeta3 integrin inhibits its activation and prevents coronary artery atherosclerosis in diabetic pigs.
The observed effects of shear stress on integrin alpha(v)beta(3) and p38 MAPK activation, as well as on FGF-2 release could be mimicked by application of pancreatic elastase to static endothelial cells.
Data show that integrin alphav, beta3, beta6 and beta8 subunit shares common structural and functional elements.
The strong expression of integrin alphaV and beta3 in mid-implantation may indicate its crucial role in successful implantation and embryo survival.
signaling events following ligand binding to alphaVbeta3 integrin reflect a balance between the effects mediated through the RGD binding site interaction and the effects mediated by the heparin binding site interaction
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
identified as receptor for foot-and-mouth disease virus
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.
These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8\; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands\; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants.
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
, alphav integrin
, integrin alpha V
, integrin alpha-V
, vitronectin receptor alpha polypeptide (VNRA)
, vitronectin receptor subunit alpha
, antigen identified by monoclonal antibody L230
, integrin alphaVbeta3
, Dnmt3l-ps1 pseudogene
, alphaV integrin
, integrin alpha v
, vitronectin receptor alpha subunit
, integrin alpha V subunit