anti-CD51 (ITGAV) Antikörper

Mouse (Murine) Integrin alpha V (ITGAV) Interaktionspartner

1. Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis

2. Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction.

3. These results demonstrate that OPN expressed by fatigue-resistant/slow motor neurons is involved in the second-wave neurodegeneration by up-regulating MMP-9 through alphavbeta3 integrin in the mouse model of amyotrophic lateral sclerosis.

4. Angiogenic activity in the atherosclerotic plaques coincides with alphavbeta3-integrin by the adventitial vasa vasorum and intraplaque neovascularization.

5. Tat PTD-Endostatin-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat PTD-Endostatin-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.

6. The synergy of circulating factor suPAR and APOL1 G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.

7. Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM.

8. Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.

9. This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.

10. the present results suggest that CS-E is capable of inhibiting OA-induced osteoclast differentiation by blocking the interaction of OA to integrin a5b3 and heparan sulfate proteoglycan .

11. These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1.

12. identify alphavbeta3 as the primary integrin heterodimer mediating shear stress-induced proinflammatory responses and as a key contributor to early atherogenic inflammation

13. Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.

14. Therapeutic delivery of alphavbeta1 inhibitor attenuated bleomycin-induced pulmonary fibrosis and carbon tetrachloride-induced liver fibrosis.

15. alphaVbeta6 integrin-deficiency results in periodontal pathogens invading gingiva and aortic adventitia and eliciting inflammasome activation.

16. These results suggest that phloretin was an inhibitor of actin podosomes and sealing zone, disrupting alpha5beta3 integrin-c-Src-Pyk2/Syk signaling pathway for the regulation of actin cytoskeletal organization in osteoclasts.

17. TN-C may enhance inflammatory responses by accelerating macrophage migration and synthesis of proinflammatory/profibrotic cytokines via integrin alphaVbeta3/FAK-Src/NF-kappaB, resulting in increased fibrosis.

18. Lung histology revealed aberrant elastin production and impaired lung septation in oxygen-exposed lungs, while tropoelastin, integrin alphav, fibulin-1, fibulin-2 and fibulin-4 gene expression were elevated.

19. Our study demonstrates that the sOPN/integrin alphav axis, which induces T cell chemotaxis toward macrophages, is critical for suppressing hyperinflammation during the first 3 h of endotoxemia.

20. Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation.

Human Integrin alpha V (ITGAV) Interaktionspartner

1. This study provides evidence that germline polymorphisms in VEGFR1, KRAS and ITGAV genes are associated with prognosis in stages II-III colon cancer patients. As stage and tumor location are correlated with prognosis, future genetic studies should stratify colon cancer patients according to these parameters.

2. Binding of small molecule ligands and radiolabelled RGD peptides is modulated by expression and activation status of alphavbeta3 integrin.

3. There is no difference in the expression of Integrin alphavbeta3 between tumor samples from glioblastomas patients with methylated or unmethylated promoter regions in the (6)O-methylguanine methyltransferase (MGMT). Further analysis of the integrin subunits via ELISA from histologic sections revealed that there is no difference in integrin subunit expression between these patients.

4. These data suggested CD51 was a predictor for the prognosis of esophageal squamous cell carcinoma patients

5. This study shows that the D2A sequence of the UPAR induces cell growth through alphaVbeta3 integrin and EGFR.

6. Cyclin D1b markedly amplified integrin alphavbeta3 expression, which was further up-regulated under lipopolysaccharide stimulation.

7. differential expression of alphavbeta3 and alphavbeta6 was examined in MDA-MB-231, MDA-MB-468 and MCF-10A cells, which signify three different stages of breast cancer development from highly metastatic to non-tumorigenic stage.

8. High expression of Integrin alphaVbeta6 is an important cause of active proliferation and impaired apoptosis in cervical cancer.

9. The results of the present study suggest that the traditional Chinese formula WD3 may inhibit gastric tumor growth, potentially via the downregulation of integrin alphav beta3 and the inhibition of ERK1/2 phosphorylation in vivo

10. of AIM-cleavage and resulting functional modification could be the basis for designing safe and efficient AIM therapy for various diseases

11. show that sCD40L/alpha5beta1 interaction leads to platelet activation as evaluated in the human whole blood

12. Among Greek and Polish patients with intracerebral hemorrhage, the rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in a codominant model of inheritance.

13. Although Mn(2+) potently activates other integrins and increases affinity of alphaVbeta6 for pro-TGF-beta1 25- to 55-fold, it increases alphaVbeta8 affinity only 2- to 3-fold.

14. ITGAVITGAVITGAV

15. This work identifies that therapeutic targeting of integrins containing an alpha V integrin unit inhibits cancer progression and thus may be of clinical benefit.

16. this study uncovers a novel pathway by which the TGFbeta-activating integrin alphavbeta8 is expressed in the human intestine on dendritic cell subsets, which is upregulated in patients with inflammatory bowel disease

17. Integrin alphavbeta3 has a role in enhancing beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations

18. BKCa has a role in promoting growth and metastasis of prostate cancer through facilitating the coupling between alphavbeta3 integrin and FAK

19. Inhibition of S. aureus ClfA binding to endothelial cell alphaV beta3 by cilengitide prevents endothelial dysfunction

20. Data show that sulfatide promoted integrin alphaV(ITGAV) expression and stimulated integrin alphaVbeta3 clustering and signaling in hepatocellular carcinoma (HCC) cells.

Pig (Porcine) Integrin alpha V (ITGAV) Interaktionspartner

1. Blocking ligand binding to the alphaVbeta3 integrin inhibits its activation and prevents coronary artery atherosclerosis in diabetic pigs.

2. The observed effects of shear stress on integrin alpha(v)beta(3) and p38 MAPK activation, as well as on FGF-2 release could be mimicked by application of pancreatic elastase to static endothelial cells.

3. Data show that integrin alphav, beta3, beta6 and beta8 subunit shares common structural and functional elements.

4. The strong expression of integrin alphaV and beta3 in mid-implantation may indicate its crucial role in successful implantation and embryo survival.

5. signaling events following ligand binding to alphaVbeta3 integrin reflect a balance between the effects mediated through the RGD binding site interaction and the effects mediated by the heparin binding site interaction

6. Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.

Cow (Bovine) Integrin alpha V (ITGAV) Interaktionspartner

1. identified as receptor for foot-and-mouth disease virus

2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

3. specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.

4. These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.