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Nectin (zeige PVRL1 Proteine)-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (zeige AMICA1 Proteine) (JAM (zeige F11R Proteine))-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 (zeige PVRL3 Proteine) and JAM (zeige F11R Proteine)-based cell-cell adhesion sites to form AJ- and TJ-like domains.
NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation.
Findings clearly reveal the structural basis for the cis (zeige CISH Proteine)-dimerization of nectins through the first Ig-like domains.
A link might exist between NECL1 and the extracellular matrix protein OPN (zeige SPP1 Proteine) in inhibiting the migration and invasion of U251 glioma ce
NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis.
Nec- 1 (zeige PCSK1 Proteine) suppress the growth and tumorigenic ability of colon cancer cells.
Necl-1 is a neural-tissue-specific Ca2 (zeige CA2 Proteine)+-independent immunoglobulin-like cell-cell adhesion molecule (zeige PCDHB16 Proteine) which potentially has membrane-associated guanylate kinase (zeige GUK1 Proteine) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
crystallographic analysis of human Nectin (zeige PVRL1 Proteine)-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule (zeige PCDHB16 Proteine)
human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS
Expression of entry receptors nectin-1 (zeige PVRL1 Proteine) and HVEM (zeige TNFRSF14 Proteine) prevent entry of HSV-1 into human conjunctival epithelium.
Our results suggest that Cadm3 may act as a negative regulator of peripheral nerve myelination, potentially through the selective regulation of the signaling cascades activated in Schwann cells by axonal contact, and in particular by type III Nrg-1 (zeige NRG1 Proteine).
Necl-1 is a neural-tissue-specific Ca2 (zeige CA2 Proteine)+-independent immunoglobulin-like cell-cell adhesion molecule (zeige PCDHb5 Proteine) which potentially has membrane-associated guanylate kinase (zeige GUK1 Proteine) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3\; MIM 607147) (Kakunaga et al., 2005
, TSLC1-like protein 1
, brain immunoglobulin receptor
, dendritic cell nectin-like protein 1 short isoform
, immunoglobulin superfamily member 4B
, immunoglobulin superfamily, member 4B
, nectin-like 1
, nectin-like protein 1
, synaptic cell adhesion molecule 3
, nectin-lke 1