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Our results support CDH7 to be a risk factor of major depressive disorder in the Han Chinese population
Cadherin-7 interacts with melanoma inhibitory activity protein (zeige MIA Proteine) and negatively modulates melanoma cell migration.
During oncogenesis, cadherin-7, N-cad and E-cad could be used as an efficient marker set for melanoma.
cadherin-7 plays an important role in the normal development of the zebrafish notochord.
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
, cadherin-7 type II