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Our results provide evidence for a widespread expression of ASIP in bovine tissues at mRNA and, for the first time, at protein level.
Possible consequences of Abr (agouti gene mutated by insertion of LINE element)for meat and milk production in cattle.
ASIP expression is significantly downregulated in human masticatory mucosa during wound healing
Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.
ASIP gene mutation is involved in the development of facial pigmented lesions.
Data show that ASIP TG/TG (zeige TG Proteine) diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma.
An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.
By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R (zeige MSHR Proteine) red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR (zeige TYR Proteine) and TYRP1 (zeige TYRP1 Proteine).
Findings suggest that ASIP locus is associated with a number of non-melanoma skin cancers.
Further analysis of binding and functional data suggests that the ASIP C-terminal loop (a six-amino-acid segment closed by the final disulfide bond) is essential for high-affinity MC1R binding and inverse agonism.
polymorphism in the agouti signaling protein gene is associated with human pigmentation
results show that men and women of similar age and BMI present similar agouti signal protein mRNA levels in omental and subcutaneous abdominal adipocytes but a sexual dimorphism exists in the relationship between its expression and BMI
Mutational analysis of the ASIP loci in relation to coat color.
there was a correlation between the recessive ASIP allele and a more independent temperament
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.
HTT (zeige HTT Proteine) is required for the apical localization of PAR3 (zeige F2RL2 Proteine)-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice.
Methylation analysis reveals that although most lines display normal methylation at IAP (zeige ALPI Proteine) elements in general, the Avy IAP (zeige ALPI Proteine) element is essentially unmethylated.
Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 (zeige SMEK1 Proteine) substrate and demonstrate that Smek1 (zeige SMEK1 Proteine) suppresses its activity.
Par3 (zeige F2RL2 Proteine) (and protein kinase C zeta (zeige PRKCZ Proteine)) are activated in neurons when binding to N2-proteoglygan.
Suggest that loss of Par3 (zeige F2RL2 Proteine) promotes metastatic behaviour of ErbB2 (zeige ERBB2 Proteine)-induced breast tumour epithelial cells by decreasing cell-cell cohesion.
Par3 (zeige F2RL2 Proteine) is identified as a regulator of signaling pathways relevant to invasive breast cancer.
The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (zeige DCTN1 Proteine) complex, and requires Cdc42 (zeige CDC42 Proteine), Par6 (zeige PARD6A Proteine) and Par3 (zeige F2RL2 Proteine).
Data suggest that aPKC phosphorylates JAM-A (zeige F11R Proteine) at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.
Brain-derived neurotrophic factor (BDNF (zeige BDNF Proteine)) induces polarized signaling of small GTPase (zeige RACGAP1 Proteine) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (zeige F2RL2 Proteine)) protein.
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
agouti signaling protein, nonagouti homolog
, agouti switch protein
, agouti-signaling protein
, nonagouti homolog
, Agouti (coat color)
, agouti signalling protein
, agouti signaling protein
, agouti-signaling protein-like
, Agouti switch protein
, Agouti-signaling protein