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conclude that the TBCD (zeige TBCD Proteine)*ARL2*beta-tubulin (zeige TUBB Proteine) complex represents a functional intermediate in the beta-tubulin (zeige TUBB Proteine) folding pathway whose activity is regulated by the cycling of nucleotides on ARL2
Results identified ARL2 and TBCD (zeige TBCD Proteine), as important in tubulin (zeige TUBB Proteine) folding and microtubule dynamics. Both ARL2 and TBCD (zeige TBCD Proteine) also localize to centrosomes. A growing body of evidence also has found roles for ARL2 inside mitochondria, as a regulator of mitochondrial fusion, and in the traffic of farnesylated cargos between membranes and specifically to cilia and photoreceptor cells. [review]
In conclusion, our study revealed that miR (zeige MLXIP Proteine)-214 acts as a tumor suppressor via inhibiting proliferation, migration and invasion of cervical cancer cells through targeting ARL2, and that both miR (zeige MLXIP Proteine)-214 and ARL2 may serve as prognostic or therapeutic targets for cervical cancer.
Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 (zeige UNC119 Proteine) Protein and Their Release by Arl2/3.
We hypothesize that ARL2 plays essential roles inside mitochondria along with other cellular functions, at least in part to provide coupling of regulation between these essential cell processes.
MiR (zeige MLXIP Proteine)-195 regulates cell apoptosis in a context-dependent manner through directly targeting ARL2.
The G proteins Arl2 acts in a GTP (zeige AK3 Proteine)-dependent manner as allosteric release factors for farnesylated cargo.
a novel function of miR-16 (zeige GDE1 Proteine) targeting ARL2 in modulating proliferation and cell cycle progression.
Data show that bovine and human TBCD (zeige TBCD Proteine) have functionally identical roles in tubulin (zeige TUBB Proteine) heterodimer assembly, and that the inability of human TBCD (zeige TBCD Proteine) to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2.
C. elegans evl-20 gene encodes a functional homolog of human ARL2. Elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation.
two pathways in mitochondria, one affecting ATP levels that is independent of ELMOD2 (zeige ELMOD2 Proteine) and the other leading to mitochondrial fusion involving MFN2 (zeige MFN2 Proteine) that does involve ELMOD2 (zeige ELMOD2 Proteine)
Studies indicate that Arf-like proteins ARL2 and ARL3 are not substrates for N-myristoyl transferase.
Arl2, a small GTPase (zeige RACGAP1 Proteine), has an important regulator of breast tumor cell aggressivity, both in vitro and in vivo
Arf-like protein 2 interaction with PDEdelta is dependent on GTP (zeige AK3 Proteine), and the binding of PDEdelta substantially stabilizes GTP binding (zeige RND2 Proteine); data suggests that Arl2/3 are specific regulators of PDEdelta
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes.
ADP-ribosylation factor-like 2
, ADP-ribosylation factor-like protein 2
, ADP-ribosylation-like 2
, arf-like protein 2