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We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling
The increased incidence of pro-arrhythmogenic Ca(2 (zeige CA2 ELISA Kits)+) sparks and waves in AnkB (zeige ANKH ELISA Kits)(+/-) hearts is due to enhanced CaMKII (zeige CAMK2G ELISA Kits)-mediated RyR (zeige RYR1 ELISA Kits) phosphorylation, which is caused by higher junctional [Ca(2 (zeige CA2 ELISA Kits)+)] and consequent local CaMKII (zeige CAMK2G ELISA Kits) activation.
The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins
Taken together, these observations reveal that AnkB (zeige ANKH ELISA Kits) is required for Prx (zeige PRX ELISA Kits) membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics.
that ankyrin-B deficiency results in a metabolic syndrome that combines primary pancreatic beta cell insufficiency with peripheral insulin (zeige INS ELISA Kits) resistance
Functional relationships between PIK3C3 (zeige PIK3C3 ELISA Kits), dynactin (zeige DCTN1 ELISA Kits), and AnkB (zeige ANKH ELISA Kits) promote axonal transport of organelles and are required for normal axon length.
These findings identify an interaction between ankyrin-B and both Cav2.1 (zeige CACNA1A ELISA Kits) and Cav2.2 (zeige CACNA1B ELISA Kits) at the amino acid level that is necessary for proper Cav2.1 (zeige CACNA1A ELISA Kits) and Cav2.2 (zeige CACNA1B ELISA Kits) targeting in vivo.
Ankyrin-B protein (zeige LEPREL2 ELISA Kits) in heart failure: identification of a new component of metazoan cardioprotection.
AnkB (zeige ANKH ELISA Kits) reduction alters cardiac Na and Ca transport and enhances the coupled RyR (zeige RYR1 ELISA Kits) openings, resulting in more frequent Ca sparks and waves although the total SR Ca leak is unaffected.
Ankyrin-B then interacts with dynactin-4 (zeige DCTN5 ELISA Kits) and dystrophin (zeige DMD ELISA Kits), whereas dynactin-4 (zeige DCTN5 ELISA Kits) collaborates with dystrophin (zeige DMD ELISA Kits) in coordinating costamere-aligned microtubules
Report disease-causing ANK2 variant localized to the membrane-binding domain resulting in reduced ankyrin-B expression and abnormal localization in a First Nations population with a high rate of long QT syndrome.
VariousANK2mutations are associated with a wide range of phenotypes, including aLQTS, especially with ventricular fibrillation, representing "ankyrin-B" syndrome.
Rare Variants in ANK2 Associated With Various Inherited Arrhythmia Syndromes.
the structures of ANK (zeige ANK1 ELISA Kits) repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 (zeige SCN2A ELISA Kits) peptide, are reported.
Gankyrin (zeige PSMD10 ELISA Kits) plays an essential role in estrogen-driven and GPR30 (zeige GPER ELISA Kits)-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling pathway.
ankyrin-B linker suppresses activity of the ANK (zeige ANK1 ELISA Kits) repeat domain through an intramolecular interaction, likely with a groove on the surface of the ANK (zeige ANK1 ELISA Kits) repeat solenoid, thereby regulating the affinities between ankyrin-B and its binding partners
Residues 63-73 of cdB3 is also essential for ankyrin binding.
Reduced ankyrin-B expression or mutations in ankyrin 2 are associated with atrial fibrillation.
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described.
ankyrin 2, neuronal
, ankyrin repeat and zinc finger domain containing protein 1
, brain ankyrin
, ankyrin B
, ankyrin, brain
, ankyrin-2, nonerythrocytic
, non-erythroid ankyrin
, ankyrin 2, brain
, ankyrin 3, epithelial