Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
The ACTN3 gene is 13.2 kb long and contains 21 exons. The equine ACTN3 gene has a ubiquitous expression but it is overexpressed in skeletal muscles
Actn3 knockout 129X1/SvJ mice gained less weight compared to wild type
Actn3 controls sarcomeric composition and muscle function in a dose-dependent fashion.
New insights that have been made in understanding the molecular mechanisms that underlie the consequences of alpha-actinin-3 deficiency.[review]
Absence of alpha-actinin-3 resulted in reduced atrophic response and altered adaptation to disuse, as measured by a change in myosin heavy chain isoform.
ACTN3 likely contributes to the regulation of bone mass through alterations in bone turnover.
Data demonstrated that the Z-disk proteins, ZASP (zeige LDB3 Antikörper), titin (zeige TTN Antikörper) and vinculin (zeige VCL Antikörper) preferentially bind to alpha-actinin-2 (zeige ACTN2 Antikörper). Thus, the loss of alpha-actinin-3 changes the overall protein composition of fast fiber Z-disks and alters their elastic properties.
Actn3 knockout mice showed differences in intrinsic exercise performance, fast muscle force generation and male muscle mass.
alpha-actinin-3 may play a role in the development of fast-twitch, glycolytic properties in a muscle fiber, and in its absence slower twitch, more oxidative properties may develop.
alpha-Actinin-3 deficiency reduces the activity of glycogen (zeige GYS1 Antikörper) phosphorylase and results in a fundamental shift toward more oxidative pathways of energy utilization--REVIEW
alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance
Study demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance.
In humans, ACTN3 genotype alone does not contribute to alterations in body mass index or obesity.
Our data indicated that ACTN3 RR genotype has higher maximal voluntary isometric contraction and lower flexibility than X-allele carriers at baseline, but the effect of ACTN3 R577X genotype on these two parameters is limited after isokinetic eccentric contractions.
RR/RX ACTN3 and ACE (zeige ACE Antikörper) DD genotypes may benefit athletes in activities that require strength and speed, while II ACE (zeige ACE Antikörper) genotype may benefit athletes in endurance activities.
findings suggest that the ACTN3 R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults.
Tthe ACTN3 R577X polymorphism is a good predictor of both the lipid profile and the prognosis of nutritional intervention in reducing LDL in HIV+ patients.
The children having both ACTN3 RR or RX genotype and ACE (zeige ACE Antikörper) DD genotype showed high systolic blood pressure and low blood HDL (zeige HSD11B1 Antikörper) cholesterol level, which may be considered a high-risk in metabolic syndrome.
This study has thus revealed a novel nuclear complex of F-actin, DRR1 (zeige FAM107A Antikörper) and COMMD1 (zeige COMMD1 Antikörper) that is involved in NF-kappaB (zeige NFKB1 Antikörper) degradation and cell cycle suppression in neuroblastoma (zeige ARHGEF16 Antikörper) cells.
The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.
p16(INK4a) expression in MCF7 breast cancer cells leads to increased cell size, weakened intercellular adhesion and cortical re-distribution of cytoskeletal F-actin.
examine the dynamics of actin in the presence of alpha-acinin in solution; suggest mechanisms to deny binding access to other actin-binding proteins and may explain how very different actin cytoskeletal structures may co-exist in the same cell
Alpha-actinin may contribute to tension sensing in actin bundles.
This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status.
, open reading frame 1
, actinin, alpha 3
, alpha 3 actinin
, F-actin cross-linking protein
, alpha-actinin skeletal muscle
, muscle alpha-actinin subunit