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These data implied that SATB1 might regulate gene expression through its different oligomerization state.
High SATB1 expression is associated with glioblastoma.
These findings suggest SATB1 may play an important role in OSCC invasiveness and metastasis.
This paper provides evidence that SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 (zeige FN1 Proteine) and PDGFRB (zeige PDGFRB Proteine).
combination of the sequence-specific and nonspecific DNA-binding modes of SATB1 should be advantageous in a search for target loci during transcriptional regulation
revealed more than 170 NFAT (zeige NFATC1 Proteine)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (zeige NFATC1 Proteine) and NFATc2 (zeige NFAT1 Proteine) in T cells, such as Raptor (zeige RPTOR Proteine), CHEK1 (zeige CHEK1 Proteine), CREB1 (zeige CREB1 Proteine), RUNX1 (zeige RUNX1 Proteine), SATB1, Ikaros (zeige IKZF1 Proteine), and Helios (zeige ZNFN1A2 Proteine).
SATB1 interacts directly with OGG1 (zeige OGG1 Proteine), increases its binding to 8-oxoG-containing DNA, promotes Schiff base formation, and stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.
High SATB1 expression in was detected in 48.3% of esophageal squamous cell carcinoma and 7.8% of normal esophagus tissues.
Silencing of special AT-rich sequence binding protein 1 inhibited the proliferation of KYSE450 and EC9706 cells which have a relatively high level of special AT-rich sequence binding protein 1, and the ability of migration and invasion of KYSE450 and EC9706 cells was distinctly suppressed.
Results suggest that SATB1 is activated to bind to chromatin at S/MARs after exposure to Abeta (zeige APP Proteine) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (zeige APP Proteine)-exposure.
SATB1cKO mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop Sjogren syndrome by 4 wk of age, soon after weaning.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (zeige GATA3 Proteine), SATB1, and IRF4 (zeige IRF4 Proteine).
these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation.
This study demonstrating that Satb1-dependent Cntn5 (zeige CNTN5 Proteine) expression in ON-OFF direction-selective ganglion cells leads to branch-specific homophilic interactions with interneurons.
we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development
this study shows that Satb1-dependent Treg cell-specific super-enhancers activation is crucial for Treg cell lineage specification in the thymus
Tumor-driven, unremitting expression of Satb1 in activated Zbtb46 (zeige ZNF340 Proteine)+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 (zeige LGALS1 Proteine) and IL-6 (zeige IL6 Proteine).
These results suggest that SATB1 plays an essential role in establishment of immune tolerance.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq (zeige GNAQ Proteine) activity.
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
SATB homeobox 1
, special AT-rich sequence binding protein 1
, AT-rich binding protein-1
, DNA-binding protein SATB1-like
, DNA-binding protein SATB1
, special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)
, special AT-rich sequence-binding protein 1