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Here we report atomic-level characterization by magic angle spinning (MAS) NMR of the muscle isoform of human cofilin 2 (CFL2) bound to F-actin. We demonstrate that resonance assignments for the majority of atoms are readily accomplished and we derive the intermolecular interface between CFL2 and F-actin.
The secreted levels of the cofilin-2 protein in radioresistant NPC patients were significantly higher than those of radiosensitive cases.
miR-3189-3p mimics enhanced the effects of the S100A4 siRNA on the inhibition of gastric cancer cell proliferation and migration by targeting CFL2.
The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer.
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
The serum lever of Alzheimer's disease were increase and the expression of clf2 strongly correlated with the Mini-Mental State Examination scores of the AD patients
In primary tumours, both desmin and CFL2 expression predicted improved overall survival in multivariate analyses
Cofilin 2 phosphorylation and genetic overexpression plays a role in the pathogenesis of idiopathic dilated cardiomyopthay.
patients with severe nemaline myopathy should be screened for mutations in CFL2.
study investigated the comparison of the levels of cofilin-1 and cofilin-2 in regressive QR-32 and progressive QRsP-11cells by western blotting
Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit.
A novel homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met) of CFL2 was identified in two siblings with congenital myopathy.
cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta
the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state
Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues
PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation
FXa-mediated sustained cofilin inactivation leads to stabilization of actin filaments incompatible with migration
actin depolymerizing factor/cofilins play an active role in establishing new interprotomer interfaces in F-actin that substitute for disrupted or weakened (as in ADP-actin) longitudinal contacts in filaments
CFL2, encoding the actin-binding protein muscle cofilin-2, is mutated in two siblings with congenital myopathy.
Resting T cells from infected patients carry significantly higher levels of active cofilin.
Examined the expression of MyHC 2x, MyHC 2b and MyHC1/slow in C2C12 cells expressing CFL2b. Results showed the level of MyHC 2x and MyHC 2b mRNA were dramatically increased compared with control cells, while the level of MyHC1/slow mRNA is not changed.
These results indicated that the mouse CFL2 gene may be involved in the regulation of MyHC via the key signaling molecules of CFL2-related signaling pathways.
miR-301a regulates Cofilin-2 in vitro in NRVCM, and in vivo in Cs1-ko mice. Our findings provide an additional and important layer of Cfl2 regulation, which we believe has an extended role in cardiac signal transduction and dilated cardiomyopathy presumably due to the reported involvement of Cfl2 in these mechanisms.
Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
deficiency of cofilin-2 is associated with interruption of the cell cycle at several checkpoints, hindering muscle regeneration
Levels of smooth muscle alpha-actin were increased and remained high in developing muscles, suggesting that cofilin2 plays a crucial role during the exchange of alpha-actin isoforms during the early postnatal remodeling of the sarcomere.
cofilin-2, although not critical for muscle development, is essential for muscle maintenance.
role of Cofilin-2 in actin dynamics
MLP binds directly to CFL2 in human cardiac and skeletal muscles.
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
cofilin, muscle isoform
, nemaline myopathy type 7
, cofilin 2 (muscle)
, cofilin 2
, LOW QUALITY PROTEIN: cofilin-2