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ADRB2 (zeige ADRB2 Proteine) gene expressed in HIV-associated neurocognitive impairment and encephalitis chaperones OPRM1, normally located intracellularly in astrocytes, to the cell surface.
These results are in line with previous studies suggesting that mu-opioid receptor signalling has been elaborated beyond its basic function of pain modulation to play an important role in managing our social encounters.
Significant interaction of OPRM1 genotype, binding potential for [(11)C]carfentanil in the ventral striatum, and relapse risk in alcoholics.
Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK (zeige EPHA3 Proteine)) cells stably transfected with one of KOP (zeige SPINT2 Proteine), MOP (zeige NLN Proteine) or DOP (zeige COPB2 Proteine)
In utero exposure to opioids is associated with increased DNA methylation (zeige HELLS Proteine) of ABCB1 (zeige ABCB1 Proteine), CYP2D6 (zeige CYP2D6 Proteine), and OPRM1 opioid-related genes in the newborn infant.
This study demonstrates that OPRM1 118A>G and the combined OPRM1/COMT (zeige COMT Proteine) genotype are associated with experimental thermal pain sensitivity in a paediatric population.
This study found significant effects for rs563649, but not rs1799971 of OPRM1, the so far most frequently analyzed opioidergic SNP in pain research.
DRD2 (zeige DRD2 Proteine) A2/A1, DRD3 (zeige DRD3 Proteine) Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 (zeige GRIK1 Proteine) rs2832407C>A are not associated with alcoholism alone or in interaction.
The OPRM1 rs1799971 A > G polymorphism is not strongly associated with alcohol-dependence. (Meta-analysis)
that promoter fragments of OPRK1 (zeige OPRK1 Proteine) and OPRM1 were able to upregulate gene expression with mild cognitive impairment
Oprm1 knock-out mice lacking 6TM genetic variants failed to show morphine-induced hyperalgesia.
Findings implicate truncated Oprm1 6TM splice variants in analgesic mechanisms and suggest that they may help explain many of the subtle, but important, clinical differences among mu opioids.
The data show that somatic MORs in POMC (zeige POMC Proteine) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
C termini generated from 3' alternative splicing of the mu opioid receptor gene are pharmacologically distinct.
Double mothering normalized the abnormal response to maternal separation in Oprm1-knockout mice, in an animal model of Autism.
OPRM1, expressed by primary afferent nociceptors, initiates opiate tolerance and opioid-induced hyperalgesia development.
Study reveals dissociable Mu opioid receptors (MOR) functions across mesocorticolimbic networks. Beyond a role in reward processing, operating at the level of local ventral tegmental area neurons, MORs also moderate motivation for appetitive stimuli within forebrain circuits that drive motivated behaviors.
MOR-T394 mutation or polymorphisms could be a risk factor in developing opioid abuse and addiction and therefore be used as a new biomarker in prediction and prevention of opioid abuse and addiction
MOR epigenetic regulation requires multiple coordinated signals converging at the MOR promoter, involving mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) activation and mitogen- and stress-activated protein kinase 1 (zeige RPS6KA5 Proteine).
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
MicroRNA miR (zeige MYLIP Proteine)-212/132 cluster is actively repressing the expression of mu opioid receptor (Oprm1) by targeting a sequence in the 3' UTR of its mRNA.
demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.
Coactivation of mu opioid receptors with nociceptin receptors produces synergistic antinociception.
Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.
micro opioid receptor isoform hMOR-1A2
, mu opiate receptor
, mu opioid receptor hMOR-1a
, mu-type opioid receptor
, MOP receptor
, mu opioid receptor splice variant rMOR-1S
, mu opioid receptor splice variant rMOR-1Z
, opioid receptor B
, opioid receptor, mu 1
, mu opioid receptor
, mu-opioid receptor
, outer membrane protein OprM