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anti-Human GPR3 Antikörper:
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Hamster Polyclonal GPR3 Primary Antibody für IHC (p) - ABIN1048790
Ledent, Demeestere, Blum, Petermans, Hämäläinen, Smits, Vassart: Premature ovarian aging in mice deficient for Gpr3. in Proceedings of the National Academy of Sciences of the United States of America 2005
Human Polyclonal GPR3 Primary Antibody für ELISA, WB - ABIN314298
Tanaka, Ishii, Kasai, Yoon, Saeki: Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth. in The Journal of biological chemistry 2007
Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2 (zeige ADRBK1 Antikörper)/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 activity.
Gpr3 stimulates Abeta (zeige APP Antikörper) production via interactions with APP (zeige APP Antikörper) and beta-arrestin2 (zeige ARRB2 Antikörper).
GPR3 is a key factor in the regulation of the nervous system and follicle development.[review]
GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse.
Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women.
We conclude that perturbations in GPR3 are not a common explanation for POF (zeige POF1B Antikörper) in this population.
These results demonstrate that GPR3 potentiates meiotic competence, most likely by raising cAMP.
GPR3 appears to have a key role in the thermogenic response of interscapular brown adipose tissue and may represent a new therapeutic target in age-related obesity.
This study found that the expression of GPR3 in CGNs exerted prosurvival effects against apoptosis-inducing stimuli, such as potassium deprivation, hypoxia, and ROS (zeige ROS1 Antikörper).
Altered signalling pathways of GPR3 could contribute to the neurobiological substrate involved in developing addiction to cocaine
Involvement of the orphan GPR3 receptor is demonstrated for the first time in expression and development of neuropathic pain and in analgesia induced by morphine.
the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis
Gpr3-defective mice may constitute a relevant model of premature ovarian failure due to early oocyte aging.
the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12 (zeige GPR12 Antikörper)
GPR3 specifically in the oocyte, rather than in the follicle cells, is responsible for maintenance of meiotic arrest in mouse oocytes.
GPR3-G(s) activation in response to stimulation of an exogenously expressed beta(2)-adrenergic receptor (zeige ADRB2 Antikörper) causes Galpha (zeige SUCLG1 Antikörper)(s) to move from the oocyte plasma membrane into the cytoplasm.
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
G protein-coupled receptor 3
, ACCA orphan receptor
, G-protein coupled receptor 3
, adenylate cyclase constitutive activator
, G protein-coupled receptor R4
, G-protein-coupled receptor R4