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This study reveals how RGS (zeige PITX2 Proteine) proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
this study shows that Galphai2 controls arrest in response to chemokine (zeige CCL1 Proteine) stimulation of neutrophils
In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning.
Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
RGS (zeige PITX2 Proteine) proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM (zeige REM1 Proteine) sleep
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (zeige RIC8A Proteine)) expression in hematopoietic cells results in a loss of GTP-binding protein (zeige DRG1 Proteine) alpha subunits Galphai2, Galphai3 (zeige GNAI3 Proteine), and Galphaq (zeige GNAQ Proteine).
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3 (zeige GNAI3 Proteine), with no evidence for functional coupling to Galphagust.
Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.
Galpha (zeige SUCLG1 Proteine)(i2) activates the TRPC4 (zeige TRPC4 Proteine) channel by direct binding.
Changes in ion selectivity and pore dilation of the TRPC4 (zeige TRPC4 Proteine) channel elicited by the Galphai2 subunit, were studied.
Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase (zeige HDAC1 Proteine) -dependent manner
These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (zeige CACNA1A Proteine) Ca(2 (zeige CA2 Proteine)+) channels
The ubiquitination of Galphai2 and Galphaq (zeige GNAQ Proteine) is suppressed by expression of Ric-8A (zeige RIC8A Proteine). The suppression likely requires Ric-8A (zeige RIC8A Proteine) interaction with these Galpha (zeige SUCLG1 Proteine) proteins; the C-terminal truncation of Galphaq (zeige GNAQ Proteine) and Galphai2 completely abrogates their interaction with Ric-8A (zeige RIC8A Proteine).
Gialpha2 plays an essential role in OXT (zeige OXT Proteine) and EGF (zeige EGF Proteine) signaling to induce prostate cancer cell migration.
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha (zeige SUCLG1 Proteine)(i2) for degradation through ubiquitination
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 2
, guanine nucleotide-binding protein G(i) subunit alpha-2
, Gi2 protein alpha-subunit
, GTP-binding regulatory protein Gi alpha-2 chain
, guanine nucleotide-binding protein G(i), alpha-2 subunit
, guanine nucleotide-binding regulatory protein alpha inhibitory subunit
, Gi-alpha-2 protein
, guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
, guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
, G alpha inhibitory type 2 (a)
, G alpha inhibitory type 2 (b)
, GTP-binding protein (G-alpha-i2)
, guanine nucleotide binding protein (G protein), alpha inhibiting 2
, guanine nucleotide binding protein, alpha inhibiting 3
, Galpha i2a
, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
, guanine nucleotide-binding protein Gi2 alpha-subunit