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These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC (zeige TRPV6 Proteine) synthesis.
crlr (zeige CALCRL Proteine) plays a nonredundant role in arterial differentiation, representing a novel element of the sonic hedgehog (zeige SHH Proteine)-vegf (zeige VEGFA Proteine)-notch (zeige NOTCH1 Proteine) signaling cascade that controls arterial/venous fate
structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy
Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (zeige CALCA Proteine) for CTR ECD (zeige SHFM1 Proteine); the same appears to apply for enhanced affinity of amylin (zeige IAPP Proteine) for RAMP2 (zeige RAMP2 Proteine)-CTR ECD (zeige SHFM1 Proteine). [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD (zeige SHFM1 Proteine) = extracellular domain; RAMP2 (zeige RAMP2 Proteine) = receptor (calcitonin) activity modifying protein 2 (zeige RAMP2 Proteine)].
Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India.
Calcitonin (zeige CALCA Proteine) and Amylin (zeige IAPP Proteine) Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis.
Data indicate a potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease.
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin (zeige CALCA Proteine), reveals ligand bias.
High calcitonin receptor is associated with prostate cancer.
the expression of CTR is associated with the early cellular events involved in atherosclerotic plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC (zeige MSC Proteine) niche.
data suggest that Clr-b (zeige CLEC2D Proteine) modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta (zeige IL1B Proteine)
Together, these data indicate that signaling through RAMP1 (zeige RAMP1 Proteine) and CLR plays a role in mediating asthma pathology
The relevance of the OPG (zeige TNFSF11 Proteine)/RANK/RANKL (zeige TNFSF11 Proteine) system in the particle-induced osteolysis process, was investigated.
Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner
Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration.
The perinatal expression of CTR within the ENS suggests that the calcitonin (zeige CALCA Proteine)/CTR system may have a role in the maturation of enteric neurons
CGRP-receptor component protein (zeige CRCP Proteine) has been found to interact only with calcitonin (zeige CALCA Proteine)-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide (zeige CALCA Proteine) signaling.
CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts.
Intracoronary intermedin (zeige ADM2 Proteine) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (zeige CALCA Proteine) receptors and beta-adrenoreceptor-mediated nitric oxide release.
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
, calcitonin receptor-like