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This study showed that sAC is essential for lysosomal acidification in addition to its other roles in cell physiology.
results suggest that the T1R3 (zeige TAS1R3 ELISA Kits) homomeric sweet taste receptor negatively regulates adipogenesis through Galphas (zeige GNAS ELISA Kits)-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway.
results implicate each subunit of the T1R2 (zeige TAS1R2 ELISA Kits)+T1R3 (zeige TAS1R3 ELISA Kits) dimer in the behavioral response to P-containing taste compounds
T1r3 (zeige TAS1R3 ELISA Kits) was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance.
T1R3 (zeige TAS1R3 ELISA Kits) and alpha-gustducin (zeige GNAT3 ELISA Kits) exhibited a stage-dependent expression pattern during mouse development, and a cell-specific pattern during the spermatogenic cycle.
Low concentration of endogenous GC is necessary and sufficient for induction of T1R3 (zeige TAS1R3 ELISA Kits) expression. Higher concentrations may inhibit such induction. This inhibitory effect may be due, at least in part, to a direct action of GC on taste cells.
T1R1 (zeige TAS1R1 ELISA Kits)/T1R3 (zeige TAS1R3 ELISA Kits) have roles in regulating ERK1/2 (zeige MAPK1/3 ELISA Kits) and mTORC1 in MIN6 cells
Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2 (zeige TAS1R2 ELISA Kits)+T1r3 (zeige TAS1R3 ELISA Kits). The other mediates cephalic phase insulin (zeige INS ELISA Kits) release but does not require an intact T1r2 (zeige TAS1R2 ELISA Kits)+T1r3 (zeige TAS1R3 ELISA Kits).
Taken together, our study raises the possibility that MyoD (zeige MYOD1 ELISA Kits) and Myogenin (zeige MYOG ELISA Kits) might control skeletal muscle metabolism and homeostasis through the regulation of T1R3 (zeige TAS1R3 ELISA Kits) promoter activity.
Mice lacking the Tas1r3 (zeige TAS1R3 ELISA Kits) taste receptor gene display impaired glucose metabolism.
results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition.
The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption.
Evaluation of soluble adenylyl cyclase expression using R21 (zeige OPRK1 ELISA Kits) antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery.
shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase
Crystal structures of human ADCY10 catalytic domains in complex with nucleotides.
Soluble adenylyl cyclase plays a role in the regulation of basal cCMP and cUMP.
sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness.
sAC is necessary for normal glucose-stimulated insulin (zeige INS ELISA Kits) secretion in vitro and in vivo.
Significant overexpression of soluble type 10 adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate carcinoma.
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
functional ADCY10 ortholog proteins exist in the heads of boar spermatozoa.
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase 10 (soluble)
, soluble adenylyl cyclase
, adenylate cyclase type 10
, germ cell soluble adenylyl cyclase
, testicular soluble adenylyl cyclase
, 3',5'-cyclic AMP synthetase
, AH-related protein
, ATP pyrophosphate-lyase
, testicular soluble adenylyl cyclase (SAC)
, adenylate cyclase type 10 variant I (full-length form)
, adenylate cyclase type 10 variant II (truncated form)
, saccharin preference protein
, sweet taste receptor T1R3
, taste receptor type 1 member 3