This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008].
CTSD
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Aktuelle Publikationen für unsere Cathepsin D Proteine
Redecker, Heckendorf, Grosch, Mersmann, Hasilik: "Molecular organization of the human cathepsin D gene." in: DNA and cell biology, Vol. 10, Issue 6, pp. 423-31, (1991) (PubMed).
Westley, May: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
Faust, Kornfeld, Chirgwin: "Cloning and sequence analysis of cDNA for human cathepsin D." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, (1985) (PubMed).
Aliase für Cathepsin D Proteine
cathepsin D (ctsd) Proteine cathepsin D (LOC398557) Proteine cathepsin D S homeolog (ctsd.S) Proteine cathepsin D (CatD) Proteine lysosomal aspartic protease (LOC5567565) Proteine cathepsin D (LOC100136761) Proteine cathepsin D (CTSD) Proteine cathepsin D (Cathd) Proteine cathepsin D (ctsD) Proteine cathepsin D (catd) Proteine cathepsin D (Ctsd) Proteine cathepsin D-like (LOC443060) Proteine catD Proteine CatD Proteine Cathd Proteine CD Proteine CLN10 Proteine CPSD Proteine CTSD Proteine DDBDRAFT_0205785 Proteine DDBDRAFT_0215012 Proteine DDB_0205785 Proteine DDB_0215012 Proteine DKFZp469J0315 Proteine fb93e11 Proteine fj17b09 Proteine LOC398557 Proteine LOC100136761 Proteine wu:fb93e11 Proteine wu:fj17b09 Proteine