anti-FABP4 (FABP4) Antikörper

Human Fatty Acid Binding Protein 4, Adipocyte (FABP4) Interaktionspartner

1. The emerging oncogenic role of liver endothelial cells through FABP4 in HCC related to MS.

2. In cardiovascular disease patients, the pericardial cavity is a distinct adipocytokine microenvironment in which especially FABP4 is mainly derived from the heart.

3. Thus, FABP4 overexpression in hepatic stellate cells may contribute to hepatocarcinogenesis in patients with metabolic risk factors by modulation of inflammatory pathways.

4. These results demonstrated that loss of A-FABP expression following a long follow-up was predictive of non-muscle invasive bladder cancer progression

5. Patient serum analysis demonstrated significantly increased FABP4 in those with underlying liver disease, particularly non-alcoholic fatty liver disease and hepatocellular carcinoma. This suggests FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and HCC cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity.

6. the expression of FABP4 might have a prognostic value in patients with breast cancer

7. Inhibition of MIR31HG reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 (FABP4).

8. the function of FABP4 in cervical cancer and the underlying molecular mechanisms, were investigated.

9. Elevation of FABP4 is associated with an increased risk of death and poor functional outcome events in patients with type 2 diabetes and acute ischemic stroke and is independent of other established clinical risk predictors and biomarkers

10. FABP4 shows potential as a novel biomarker for diabetic retinopathy prediction in Chinese patients with type 2 diabetes (T2DM), and strict glycemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4.

11. association between serum FABP4 concentrations and sarcopenia in chronic hemodialysis patients

12. intermittent high glucose potentiates A-FABP activation and inflammatory responses via TLR4/p-JNK signaling in THP-1 cells

13. High serum A-FABP concentration is associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus.

14. FABP4 from adipocytes mediate adipocyte-cholangiocarcinoma interactions that are crucial for the invasion, migration and epithelial-mesenchymal transition of cholangiocarcinoma cells

15. Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age, systolic blood pressure, pulse pressure, duration of kidney transplantation and serum A-FABP

16. Blood FABP4 is a biomarker for metabolic syndrome and cardiovascular disease independently of HIV status and antiretroviral therapy.

17. Increased FABP4 blood level is a biomarker of lead exposure in women.

18. ubiquitylation destabilizes the fold of two proteins, FKBP12 and FABP4

19. Compared to control group, breast cancer patients show higher FABP4 and FABP5 blood levels. Our data suggest that, particularly, circulating FABP4 levels could be considered a new independent breast cancer biomarker. Our work translates basic science data to clinic linking the relationship between adipose tissue and lipid metabolism to breast cancer.

20. findings reveal a pro-angiogenic role of FABP4 in first trimester placental trophoblast cells and its regulation may have impact in placental physiology.

Cow (Bovine) Fatty Acid Binding Protein 4, Adipocyte (FABP4) Interaktionspartner

1. Studied SNPs in cattle Fatty Acid Binding Protein 4 (FABP4) in several cattle breeds and evaluated possible associations with regards to meat quality and fat content of the meat.

2. Overexpressed FABP4 of different genotypes in bovine intramuscular preadipocytes and studied the intracellular localization of FABP4 and the expression levels of lipid metabolism-related genes among different genotypes.

3. These results provide an important basis for further understanding the regulation of bovine FABP4.

4. This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.

5. Data show that overexpression of cattle adipocyte fatty acid-binding protein (A-FABP)gene promoted fat deposition in the skeletal muscle of transgenic mice.

6. FABP4 gene frequency and SNP genotypes in Holstein-Friesian cows and its relationship with protein and fat content in milk

7. polymorphisms can be used to select for milk with lower concentrations of saturated fatty acids and higher concentrations of unsaturated fatty acids

8. The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

9. The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested.

10. re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism.

11. The FABP4 gene falls into a suggestive/significant quantitative trait loci interval for beef marbling.

12. Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence back fat thickness in beef cattle.

13. FABP4 I74V polymorphism had a significant effect on palmitoleic acid composition in intramuscular fat.

14. A splice site single nucleotide polymorphism of the fatty acid binding protein 4 gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle.

Pig (Porcine) Fatty Acid Binding Protein 4, Adipocyte (FABP4) Interaktionspartner

1. FABP4 gene expression level in adipose tissue was higher than in muscle. In contrast, FABP5 was expressed at low levels in adipocytes and muscle tissues. Low and moderate correlations between FABP4 and FABP5 gene expression were observed in muscle and in backfat, respectively.

2. the A-FABP gene is strongly related to the development and function of intramuscular fat accretion in pigs.

3. AFABP is significantly increased in coronary artery in-stent restenosis segments of both diabetic and nondiabetic minipigs.

4. Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits.

5. Monitoring of posttransplant L-FABP plasma levels is a valuable new tool to quantify early the extent of parenchymal cell damage of non-heart-beating donors in liver transplantation.

6. study suggests that FABP-4 protein content may be a valuable marker of lipid accretion

7. A study of the mapping characteristics and relationship to body composition of FAT1 and FABP4 in swine is reported.

8. regenerated coronary endothelial cells exhibit upregulation of adipocyte fatty acid binding protein (A-FABP)

Mouse (Murine) Fatty Acid Binding Protein 4, Adipocyte (FABP4) Interaktionspartner

1. Livers from obese mice, independent of tumour status, exhibited increased FABP4 mRNA and protein expression concomitant with elevated serum FABP4. The data suggest FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and hepatocellular carcinoma cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity.

2. results proved that the REV-ERB agonism inhibited osteoclastogenesis partially via FABP4 up-regulation.

3. The findings chart the pathway of FABP4 secretion and provide a potential therapeutic means to control metabolic disorders associated with its dysregulated secretion.

4. Study in A-FABP knockout mice revealed that A-FABP acts as a physiological stimulator of brown adipose tissue-mediated adaptive thermogenesis.

5. Fabp4/5 confers protection against metabolic diseases but does not extend lifespan.

6. Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury.

7. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages

8. Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.

9. Collectively, these results demonstrate that C. pneumoniae exploits host FABP4 to facilitate fat mobilization and intracellular replication in adipocytes. This work uncovers a novel strategy used by intracellular pathogens for acquiring energy via hijacking of the host lipid metabolism pathway.

10. High Fabp4 expression is associated with Acute myeloid leukemia.

11. These data suggest that the function of SIRT6 in the Fabp4-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.

12. This study demonstrating a FABP4-UCP2 axis with the potential to modulate the microglial inflammatory response.

13. our data establish A-FABP as a new molecular sensor in triggering macrophage-associated sterile inflammation in obesity.

14. these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.

15. FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis.

16. endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes

17. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 and SirT3.

18. FABP4 could reverse the activation of the leptin-induced mitochondrial fatty acid oxidation.

19. FABP4 is a hypoxia inducible gene that sensitizes mice to liver I/R injury.

20. Data suggest Fabp4 is up-regulated and DNA methylation is down-regulated in aorta in hyperhomocysteinemia induced by high-methionine diet; up-regulation of DNA methyltransferase 1 (Dnmt1) promotes DNA methylation and decreases Fabp4 expression.

Wheat germ Fatty Acid Binding Protein 4, Adipocyte (FABP4) Interaktionspartner

1. Cloning and characterization of the gene and its homology with other species.

2. results indicated that an A-FABP gene polymorphism was associated with abdominal fat weight and percentage of abdominal fat, and the A-FABP gene could be a candidate locus or linked to a major gene(s) that affects abdominal fat content in the chicken