anti-CEBPA (CEBPA) Antikörper

Human CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. The earliest steps of adult hepatocellular carcinoma and aggressive pediatric liver cancer have identical features that include conversion of the tumor suppressor C/EBPalpha into an oncogenic isoform, which further creates preneoplastic foci where hepatocytes dedifferentiate into cancer cells, giving rise to liver cancer

2. Data suggest that up-regulation of NPY (zeige NPY Antikörper) inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG (zeige PPARG Antikörper), CEBPA, CIDEC (zeige CIDEC Antikörper), and RIP140 (zeige NRIP1 Antikörper). (NPY (zeige NPY Antikörper) = neuropeptide Y (zeige NPY Antikörper); PPARG (zeige PPARG Antikörper) = peroxisome proliferator activated receptor gamma (zeige PPARG Antikörper); CIDEC (zeige CIDEC Antikörper) = cell death-inducing DFFA-like effector C (zeige CIDEC Antikörper); RIP140 (zeige NRIP1 Antikörper) = nuclear receptor interacting protein 1 (zeige NRIP1 Antikörper))

3. Study identified for the first time that HNF4alpha (zeige HNF4A Antikörper) and C/EBPalpha are important transcriptional regulators for FBP1 (zeige FBP1 Antikörper) expression in human hepatoma HepG2 cells.

4. The presence of biallelic CEBPA mutations is a favourable prognostic feature in acute myeloid leukaemia.

5. C/EBP-alpha mediates anti-inflammatory effects in podocytes

6. proteogenomics profiling study reveals that an activation of C/EBPalpha, along with the upregulation of its lipogenesis targets, accounts for lipid storage and acts as a hallmark of ARVC ( Arrhythmogenic right ventricular cardiomyopathy)

7. Taken together, the authors propose that the miR (zeige MLXIP Antikörper)-939-Jmjd3 (zeige Kdm6b Antikörper) axis perturbs the accessibility of hepatitis B virus enhancer II/core promoter (En II) promoter to essential nuclear factors (C/EBPalpha and SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complex) therefore leading to compromised viral RNA synthesis and hence restricted viral multiplication.

8. EBPA and RUNX1 (zeige RUNX1 Antikörper) are expressed at higher levels in patients with acute myeloid leukemia (zeige BCL11A Antikörper) in comparison to healthy subjects

9. Integration of WGS-based fine-mapping and complementary epigenomic datasets provided evidence for causal mechanisms at several loci, including at a previously undiscovered basophil count-associated locus near the master hematopoietic transcription factor CEBPA The fine-mapped variant at this basophil count association near CEBPA overlapped an enhancer active in common myeloid progenitors and influenced its activity.

10. in our study on a large cohort of CEBPAmut AML (zeige RUNX1 Antikörper) patients, we found a high coincidence of GATA2mut, in particular within the subgroup of patients with CEBPAbi mutations

Mouse (Murine) CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. The earliest steps of adult hepatocellular arcinoma and aggressive pediatric liver cancer have identical features that include conversion of the tumor suppressor C/EBPalpha into an oncogenic isoform, which further creates preneoplastic foci where hepatocytes dedifferentiate into cancer cells, giving rise to liver cancer

2. C/EBP-alpha mediates anti-inflammatory effects in podocytes

3. under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Antikörper) activity, TRIB3 (zeige TRIB3 Antikörper) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21 (zeige FGF21 Antikörper).

4. the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa), CCAAT enhancer-binding protein beta (C/EBPb (zeige CEBPB Antikörper)), and gamma receptors by peroxisome proliferators (PPARg (zeige PPARG Antikörper)), during adipogenesis

5. shown that ectopic miR (zeige MLXIP Antikörper)-155 expression and loss of C/EBPA expression in myeloid progenitor cells cooperate in transformation of HSPCs toward AML (zeige RUNX1 Antikörper) in the absence of FLT3 (zeige FLT3 Antikörper)-ITD

6. The Bach2 (zeige BACH2 Antikörper)-C/EBPbeta (zeige CEBPB Antikörper) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.

7. Data demonstrate the importance of a controlled balance between C/EBPalpha and miR (zeige MLXIP Antikörper)-182 for the maintenance of healthy granulopoiesis.

8. Functional characterization of C/EBPa and C/EBPb (zeige CEBPB Antikörper) proteomes suggests they can regulate novel pathways.

9. results indicate that JMJD2B (zeige KDM4B Antikörper) regulates PPARgamma (zeige PPARG Antikörper) and C/EBPalpha during adipogenesis

10. A single +42-kb enhancer is essential for CEBPA expression in myeloid cells only.

Zebrafish CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. C/ebpalpha plays a role in liver growth regulation via the p53 (zeige TP53 Antikörper) pathway.

2. Dnmt1 (zeige DNMT1 Antikörper) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish

3. Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (zeige ALDH1L1 Antikörper)) involving CEBPalpha helps relieve embryonic oxidative stress induced (zeige SQSTM1 Antikörper) by ethanol exposure.

4. Bmi1 (zeige BMI1 Antikörper) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.

5. Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (zeige SUMO1 Antikörper), SUMO2 (zeige SUMO2 Antikörper), and SUMO3 (zeige SUMO3 Antikörper)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.

6. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (zeige CTNNA1 Antikörper) axis controls myeloid development and transformation.

Xenopus laevis CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (zeige IL6 Antikörper)-mediated repression

Cow (Bovine) CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.

2. Expressions of C-EBPalpha and myostatin (zeige MSTN Antikörper) in muscles were higher in the concentrate-fed group than in the grass hay (zeige GTF2H5 Antikörper)-fed group.

Pig (Porcine) CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) Interaktionspartner

1. C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.

2. The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.