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anti-Human CEBPA Antikörper:
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Human Monoclonal CEBPA Primary Antibody für FACS, ICC - ABIN269606
Ferrari-Amorotti, Keeshan, Zattoni, Guerzoni, Iotti, Cattelani, Donato, Calabretta: Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha. in Blood 2006
Show all 4 Pubmed References
Cow (Bovine) Polyclonal CEBPA Primary Antibody für IHC, WB - ABIN2787465
Singh, Trivedi, Behre: C/EBPalpha S248A mutation reduces granulocytic differentiation in human leukemic K562 cells. in Biochemical and biophysical research communications 2008
Show all 3 Pubmed References
Human Monoclonal CEBPA Primary Antibody für FACS, ELISA - ABIN969507
Geest, Buitenhuis, Vellenga, Coffer: Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. in Haematologica 2009
Human Monoclonal CEBPA Primary Antibody für ICC, FACS - ABIN969048
Jin, Zhang, Yan, Liu, Wang, Ge, Zhai: C/EBPalpha regulates SIRT1 expression during adipogenesis. in Cell research 2010
a decision analysis comparing allo-HCT vs chemotherapy in first complete remission for patients with cytogenetically intermediate-risk acute myeloid leukemia (zeige BCL11A Antikörper), depending on the presence or absence of FLT3 (zeige FLT3 Antikörper)-ITD), NPM1 (zeige NPM1 Antikörper), and CEBPA mutations showed that allo-HCT was a favored postremission strategy in patients with FLT3 (zeige FLT3 Antikörper)-ITD, and chemotherapy was favored in patients with biallelic CEBPA mutations.
This is the first study providing evidence that the c.690G>T, p.(Thr230Thr) (rs34529039) polymorphism of the CEBPA gene, together with up-regulation of its mRNA expression, are negative factors worsening ovarian cancer outcome
CSF3R (zeige CSF3R Antikörper) mutations co-occur with CEBPA mutations in pediatric acute myeloid leukemia (zeige BCL11A Antikörper).
While much is known about how C/EBPalpha orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPalpha deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBPA mutations
miR-182 is a strong regulator of C/EBPalpha. There is a regulatory loop between C/ (zeige MLXIP Antikörper)EBPalpha and miR-182. While C/EBPalpha blocks miR-182 expression by direct promoter binding during myeloid differentiation, enforced expression of miR-182 reduces C/EBPalpha protein level and impairs granulopoiesis in vitro and in vivo.
CHOP (zeige DDIT3 Antikörper) negatively regulates Polo-like kinase 2 (zeige PLK2 Antikörper) expression via recruiting C/EBPalpha to the upstream-promoter in human osteosarcoma cell line during ER stress
C/EBPalpha overexpression suppressed the epithelial-mesenchymal transition (EMT (zeige ITK Antikörper)) that was characterized by a gain of epithelial and loss of mesenchymal markers. Further study showed that C/EBPalpha suppressed the transcription of beta-catenin (zeige CTNNB1 Antikörper) and downregulated the levels of its downstream targets.
Binding of C/EBPalpha was associated with increased deacetylation near the transcription start site (TSS (zeige RPL38 Antikörper)) of the PLK1 (zeige PLK1 Antikörper) promoter.
a MEF2C and CEBPA correlation in CML disease progression
CEBPA gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.
The Bach2 (zeige BACH2 Antikörper)-C/EBPbeta (zeige CEBPB Antikörper) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data demonstrate the importance of a controlled balance between C/EBPalpha and miR (zeige MLXIP Antikörper)-182 for the maintenance of healthy granulopoiesis.
Functional characterization of C/EBPa and C/EBPb (zeige CEBPB Antikörper) proteomes suggests they can regulate novel pathways.
results indicate that JMJD2B (zeige KDM4B Antikörper) regulates PPARgamma (zeige PPARG Antikörper) and C/EBPalpha during adipogenesis
A single +42-kb enhancer is essential for CEBPA expression in myeloid cells only.
these data indicate that CycC (zeige CCNC Antikörper) activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha, PPAR-gamma (zeige PPARG Antikörper), FAS (zeige FAS Antikörper), perilipin A (zeige PLIN1 Antikörper), and STAT-3 (zeige STAT3 Antikörper).
we show that SIX1 (zeige SIX1 Antikörper) binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb (zeige CEBPB Antikörper) and EBF2 (zeige EBF2 Antikörper), suggesting their functional cooperation during adipogenesis.
these results indicate that C/EBPalpha functions throughout osteoclastogenesis as well as in Osteoclast function. This study provides additional understanding of the roles of C/EBPalpha in Osteoclast biology.
the DNA sequences to which EVI1 (zeige MECOM Antikörper) binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1 (zeige MECOM Antikörper)-induced suppression.
C/ebpalpha plays a role in liver growth regulation via the p53 (zeige TP53 Antikörper) pathway.
Dnmt1 (zeige DNMT1 Antikörper) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (zeige ALDH1L1 Antikörper)) involving CEBPalpha helps relieve embryonic oxidative stress induced (zeige SQSTM1 Antikörper) by ethanol exposure.
Bmi1 (zeige BMI1 Antikörper) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1, SUMO2, and SUMO3) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (zeige CTNNA1 Antikörper) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (zeige IL6 Antikörper)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (zeige MSTN Antikörper) in muscles were higher in the concentrate-fed group than in the grass hay (zeige GTF2H5 Antikörper)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha