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BRCA1 Proteine

(Breast Cancer 1 (BRCA1))
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

12 Treffer

BRCA1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Produktnummer ABIN1346847
 
BRCA1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Produktnummer ABIN1346845
 
BRCA1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7505164
 
BRCA1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7504943
 
BRCA1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA
Produktnummer ABIN7575209
 
BRCA1 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Produktnummer ABIN7415059
 
BRCA1 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC
Produktnummer ABIN7403681
 
BRCA1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC
Produktnummer ABIN7393967
 
BRCA1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % pure WB, SDS, ELISA
Produktnummer ABIN2128207
 
BRCA1 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
Produktnummer ABIN3008532
 
BRCA1 Spezies: Human Wirt: Insektenzellen Recombinant > 95 % SDS
Produktnummer ABIN1951924
 
BRCA1 Spezies: Human Wirt: Baculovirus Recombinant The purified recombinant protein is greater than 95 % homogeneous and contains no detectable protease, DNase and RNase activity. in vitro, ProA, PI
Produktnummer ABIN2669409
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Immunoprecipitation (IP)
    • In vitro Assay (in vitro)
    • Proliferation Assay (ProA)
    • Protein Interaction (PI)
  • Reaktivität
    • Human
    • Rat
    • Mouse
  • Abbildungen verfügbar
  • Wirt
    • Escherichia coli (E. coli)
    • Wheat germ
    • Baculovirus
    • Insect Cells
  • Bindungsspezifität
    • AA 1-59
    • AA 1524-1781
    • AA 1564-1863
    • AA 1579-1811
    • AA 1581-1670
    • AA 1610-1863
    • AA 19-83
  • Konjugat
    • His tag
    • Unkonjugiert
    • GST tag
    • His tag,GST tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Hersteller
    • antibodies-online
    • Abbexa
    • Active Motif
    • Neuromics Antibodies

Aliase für BRCA1 Proteine

BRCA1, DNA repair associated (BRCA1) Proteine
breast cancer 1 (brca1) Proteine
breast cancer 1, early onset (LOC755086) Proteine
breast cancer 1, early onset (Brca1) Proteine
BRCA1, DNA repair associated (Brca1) Proteine
breast cancer 1, early onset (BRCA1) Proteine
breast cancer 1 L homeolog (brca1.L) Proteine
brca1 Proteine
BRCA1 Proteine
BRCAI Proteine
brcai Proteine
BRCC1 Proteine
brcc1 Proteine
BROVCA1 Proteine
IRIS Proteine
iris Proteine
LOC100224649 Proteine
PNCA4 Proteine
PPP1R53 Proteine
PSCP Proteine
pscp Proteine
RNF53 Proteine
rnf53 Proteine
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