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Our findings thus indicate that the FKBP38-ANKMY2 (zeige ANKMY2 Antikörper) axis plays a key role in regulation of Shh (zeige SHH Antikörper) signaling in vivo.
In pre-hearing time Fkbp8-specific signal was also observed in the tectorial membrane, whose alpha- and beta-Tectorin (zeige TECTB Antikörper) components show similar time-dependent expression of mRNA as Fkbp8.
used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8, and subsequently for Fkbp1a (zeige FKBP1A Antikörper).
Results show that FKBP8 is an essential antagonist of sonic hedgehog (zeige SHH Antikörper) signaling in central nervous system development.
FKBP38 functions to anchor the 26S proteasome (zeige Psmd4 Antikörper) at the organellar membrane
Gene expression analysis of Fkbp8 mutants revealed a perturbation of expression of neural tube patterning genes, suggesting that endogenous FKBP8 activity establishes dorso-ventral patterning of the neural tube.
Findings suggest that FKBP38 is required for neuroectodermal organization during neural tube formation as a result of its anti-apoptotic activity and regulation of neurite extension
Disruption of FKBP8 function activates the Shh (zeige SHH Antikörper) signaling pathway cell-autonomously dependent on the Gli2 (zeige GLI2 Antikörper) transcription factor and kinesin-2 (zeige KIF2A Antikörper) subunit Kif3a (zeige KIF3A Antikörper), a component of the intraflagellar transport machinery used to generate cilia.
Data indicate that PHD2 (zeige EGLN1 Antikörper) protein stability is regulated by a ubiquitin-independent proteasomal pathway involving FKBP38 as adaptor protein that mediates proteasomal interaction.
Co-expression of FKBP8 with LC3A (zeige MAP1LC3A Antikörper) profoundly induces Parkin (zeige PARK2 Antikörper)-independent mitophagy. Strikingly, even when acting as a mitophagy receptor, FKBP8 avoids degradation by escaping from mitochondria. In summary, this study identifies novel roles for FKBP8 and LC3A (zeige MAP1LC3A Antikörper), which act together to induce mitophagy.
FKBP8 binding to Hsp90 (zeige HSP90 Antikörper) did not substantially influence its ATPase (zeige DNAH8 Antikörper) activity
The information presented here provides important clues for understanding the catalytic activity of FKBP38, its regulation by the unique N-terminal extension, and the potential calcium- and calmodulin-mediated activation of FKBP38.
Overexpression of permanently active S100P (zeige S100P Antikörper) in Huh-7 cells inhibited the interaction of FKBP38 with Bcl-2 (zeige BCL2 Antikörper), resulting in the suppression of Bcl-2 (zeige BCL2 Antikörper) stability
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR (zeige CFTR Antikörper)) folding and stability
The derived structure model of the complex between Bcl-2 (zeige BCL2 Antikörper) and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 (zeige BCL2 Antikörper) interaction by Ca(2 (zeige CA2 Antikörper)+).
Data support a dual role for FKBP38 in regulating CFTR (zeige CFTR Antikörper) synthesis and post-translational folding.
a dual mechanism for PA activation of mTORC1: PA displaces FKBP38 from mTOR (zeige FRAP1 Antikörper) and allosterically stimulates the catalytic activity of mTORC1.
this charge-sensitive site in the FKBP (zeige FKBP7 Antikörper) domain participates in the regulation of FKBP38 function by enabling electrostatic interactions with ligand proteins and/or salt ions such as Ca(2 (zeige CA2 Antikörper)+)
These results demonstrate that FKBP38 is a novel regulator of the oncogenic protein PRL-3 abundance and that alteration in the stability of PRL-3 can have a dramatic impact on cell proliferation.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.
peptidyl-prolyl cis-trans isomerase FKBP8
, FK506 binding protein 8, 38kDa
, peptidyl-prolyl cis-trans isomerase FKBP8-like
, FK506-binding protein 8
, 38 kDa FK506-binding protein
, 38 kDa FKBP
, FK506-binding protein 38
, PPIase FKBP8
, FK506-binding protein 8 (38kD)