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Human NME1 Protein expressed in Wheat germ - ABIN1312683
Yang, Chevolot, Géhin, Solassol, Mange, Souteyrand, Laurenceau: Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera. in Biosensors & bioelectronics 2012
Results demonstrate that nm23 plays a vital role in decidualization in mice and humans and that nm23 gene expression is hormonally regulated.
NM23 might be an indicator of good prognosis in patients with breast cancer, although further researches need to be performed to confirm the prognostic value of NM23. [Meta-analysis; review]
The data presented suggest an important role for cytoplasmic IRF6 (zeige IRF6 Proteine) in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development.
High NME1 expression is associated with well tumor differentiation in Digestive System Neoplasms
Hepatitis C Virus E1 protein expression and HCV infection induces pro-metastatic effect on cancer cells which is simultaneous to Nm23-H1 transcriptional down-regulation and Nm23-H1 protein degradation.
Meta-analysis showed that low expression of nm23-H1 is associated with poorer prognosis in patients with nasopharyngeal carcinoma, suggesting that it is a prognostic factor and potential biomarker for survival in nasopharyngeal carcinoma.
Nm23-H1 nuclear localized mainly in the G2/M phase and the nuclear Nm23-H1 promoted A549 cell proliferation in vitro.
Differential regulation of NM23-H1 may corroborate/abrogate EMT (zeige ITK Proteine) depending on the nature of stress, tumor microenvironment and cellular context.
large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting gastric cancer progression.
Study reveals that NME1L may perform potent biological roles on the cellular behaviors through the extra N-terminal region as well as hexameric conformation. Because the N-terminal region itself has no effect on NF-kappaB (zeige NFKB1 Proteine) signaling, the dimerization of NME1L is likely a pivotal process to confer the IKKbeta (zeige IKBKB Proteine) binding ability and subsequent regulation of NF-kappaB (zeige NFKB1 Proteine) signaling on the region.
Deletion of NME1 reduced total NDPK activity and exacerbated activation of the stress-related MAPK (zeige MAPK1 Proteine), JNK (zeige MAPK8 Proteine), in the liver in response to paraquat. NDPK activity protects cells from acute oxidative stress by inhibiting activation of JNK (zeige MAPK8 Proteine) in mammal models.
EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase
data suggested that NME1 acts as a switcher or reprogramming factor which involves in oligodentrocyte versus neuron cell fate specification in vitro
NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma.
NME1 controls annexin IV (zeige ANXA4 Proteine) and EF-1Balpha amounts by post-translational mechanisms.
data show a critical role for NM23 isoforms in limiting mutagenesis and suppressing UVR-induced melanomagenesis
GAPDH (zeige GAPDH Proteine) and NDPK are genetic modifiers of murine DDC (zeige DDC Proteine)-induced liver injury
The work provides a rare instance of nm23-1/NDPKA physiological functions in the mammary glands and reveals its implication as a modulator factor of proliferation and apoptosis in this tissue.
Ha-ras oncogene (zeige RAB1A Proteine) regulates morphogenesis, tumorigenesis, and metastasis through suppressing nm23 expression and modulation of immune cell function
Data suggested that nm23-M1/NDPK A was involved in the process of blastocyst implantation.
NDPKB is required for VEGF (zeige VEGFA Proteine)-induced angiogenesis and contributes to the correct localization of VEGF receptor (zeige FLT1 Proteine) type 2 and VE-cadherin (zeige CDH5 Proteine) at the endothelial adherens junctions.
Data show that NDPK B knockdown embryo results in a severe decrease in cardiac contractility.
NDPK-A exists in a functional cellular complex with AMPK (zeige PRKAA2 Proteine) and CFTR (zeige CFTR Proteine) in airway epithelia, and NDPK-A catalytic function is required for the AMPK (zeige PRKAA2 Proteine)-dependent regulation of CFTR (zeige CFTR Proteine)
The physical interaction between phytochrome A in the Pfr form and NDPK-In results in a significant increase in the kinase activity of NDPK-In. The results presented in this work indicate that NDPK-In may function as a protein kinase regulated by light.
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
NDP kinase A
, granzyme A-activated DNase
, metastasis inhibition factor nm23
, non-metastatic cells 1, protein (NM23A) expressed in
, nucleoside diphosphate kinase A
, tumor metastatic process-associated protein
, NDK A
, expressed in non-metastatic cells 1 protein
, expressed in non-metastatic cells 1, protein
, metastasis inhibition factor NM23
, nucleoside-diphosphate kinase 1
, nucleotide diphosphate kinase
, NDP kinase beta
, expressed in non-metastatic cells 1 protein (NM23A) (nucleoside diphosphate kinase)
, expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase)
, nucloside diphosphate kinase
, non-metastatic cells 2, protein (NM23B) expressed in
, non-metastatic cells 2b.1, protein (NM23B) expressed in
, nucleoside diphosphate kinase-Z1
, NME1-NME2 readthrough transcript
, expressed in non-metastatic cells 1
, NDK A2
, NDP kinase A2
, NM23/nucleoside diphosphate kinase A2
, ndk a1
, nucleoside diphosphate kinase A2
, NDK A 1
, NDK A 2
, NDK NBR-A
, NDK NBR-B
, NDP kinase A 1
, NDP kinase A 2
, nucleoside diphosphate kinase A 1
, nucleoside diphosphate kinase A 2
, nucleoside diphosphate kinase NBR-A
, nucleoside diphosphate kinase NBR-B
, nucleoside-diphosphate kinase NBR-A
, nucleoside-diphosphate kinase NBR-B
, NDK A1
, NDP kinase A1
, NM23/nucleoside diphosphate kinase A1
, ndk a2
, nucleoside diphosphate kinase A1
, NDP kinase I
, nucleoside diphosphate kinase 1
, nucleoside diphosphate kinase I
, NDK I
, NDPK I
, Nucleoside diphosphate kinase I