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case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.
Caspase-10 is a negative regulator of cell death and a facilitator of gene induction separates the function of cFLIP (zeige CFLAR Proteine) and caspase-10 in the death-inducing signaling complex.
caspase-10 was dispensable for enhancement of cisplatin/LA-12 and TRAIL combination-induced cell death and stimulation of Bid (zeige BID Proteine) cleavage
This study reveals an essential role of SUMOylated FADD (zeige FADD Proteine) in Drp1 (zeige CRMP1 Proteine)- and caspase-10-dependent necrosis.
Three cases of autoimmune lymphoproliferative syndrome due to somatic FAS (zeige FAS Proteine) mutation (ALPS-sFAS) combined with a germline CASP10 variation have been described.
Levels of caspase-9 (zeige CASP9 Proteine), caspase-10, MAVS (zeige MAVS Proteine), and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in the systemic lupus erythematosus patients were determined.
Results showed miR (zeige MLXIP Proteine)-221/222 promote cell proliferation and repress apoptosis, through suppressing caspase-10, in prostate cancer cells.
We have also demonstrated that these correlations are tissue specific being reduced (CASP9 (zeige CASP9 Proteine) and CASP10) or different (CASP2 (zeige CASP2 Proteine)) in the liver
proinflammatory (caspase 1 (zeige CASP1 Proteine)) and initiator (caspases 8 and 10) caspases in the syncytiotrophoblast and capillary endotheliocytes of the terminal villi are higher in induced pregnancies.
Single nucleotide polymorphisms in CASP10 gene is associated with gastric cancer.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, caspase 10, apoptosis-related cysteine protease
, FADD-like ICE2
, FAS-associated death domain protein interleukin-1B-converting enzyme 2
, ICE-like apoptotic protease 4
, apoptotic protease MCH-4
, interleukin-1B-converting enzyme 2