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BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma.
inhibition of the BCL2 family member BCLxL resulted in nanomolar potency against human synovial sarcoma cell lines and 50% tumor reduction in a genetically engineered mouse model
In this study, we investigated whether APG (zeige SMAD1 Proteine)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (zeige TIMM8A Proteine) assay.APG-1252-12A is a Bcl-2 (zeige BCL2 Proteine) homology (BH)-3 mimetic that specifically binds to Bcl-2 (zeige BCL2 Proteine) and Bcl-xl, which has shown efficacy in some Bcl-2 (zeige BCL2 Proteine) dependent hematological cancers
inhibition of Bcl-xL induces significantly more apoptosis in IDH1 (zeige IDH1 Proteine)-mutated cells than in wild-type IDH1 (zeige IDH1 Proteine) cells.
CCAT1 is upregulated in docetaxel-resistant lung adenocarcinoma cells; its oncogenic function depends on sponging of let-7c, which releases Bcl-xl, promoting the acquisition of chemoresistance and epithelial-to-mesenchymal transition phenotypes
In the epithelial ovarian cancer stem cells, 40% knock-down of Bclxl expression was sufficient to induce the full activation of caspases. Bclxl expression levels in EOC cells is dynamic and can be regulated by microenvironments that are enriched with the pro-inflammatory cytokine IL-6 (zeige IL6 Proteine) such as the cancer stem cell and adipocyte niches.
Study reports the interaction of BCL-XL with RASSF6 (zeige RASSF6 Proteine). BCL-XL inhibits the interaction between RASSF6 (zeige RASSF6 Proteine) and MDM2 (zeige MDM2 Proteine) and suppresses p53 (zeige TP53 Proteine) expression. Consequently, BCL-XL antagonizes RASSF6 (zeige RASSF6 Proteine)-mediated apoptosis. Thus, the inhibition of RASSF6 (zeige RASSF6 Proteine)-mediated apoptosis also underlies the prosurvival role of BCL-XL.
anti-apoptotic molecules BclxL and Bcl-2 (zeige BCL2 Proteine) and the pro-apoptotic factors BAD and BID (zeige BID Proteine) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (zeige FASL Proteine).
These results show that mRNA expression in centenarians is unique and reveals that Bcl-xL plays an important role in exceptional aging.
that Ubiquitin-specific peptidase 18 (zeige USP18 Proteine) directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells
targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling.
GATA-3 (zeige GATA3 Proteine) participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2 (zeige RUNX2 Proteine).
this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl
Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway.
Proapoptotic proteins BIM (zeige BCL2L11 Proteine) and PUMA (zeige BBC3 Proteine) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
BMP4 (zeige BMP4 Proteine) promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4 (zeige BMP4 Proteine)-Smad1 (zeige SMAD1 Proteine)/5/8-Id1 (zeige ID1 Proteine) signaling in the presence of FGF-2 (zeige FGF2 Proteine).
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Proteine) and the interaction between the GR and Bim (zeige BCL2L11 Proteine), Bcl-xL and Bak (zeige BAK1 Proteine) could play a role in the regulation of thymocyte apoptosis.
Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord.
amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
interleukin-6 (zeige IL6 Proteine), endothelin ET-1 (zeige EDN1 Proteine), and apoptotic Bak (zeige BAK1 Proteine) and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (zeige BCL2 Proteine) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.
Bcl-Xl deamidation and methylation has a role in protein isoaspartate methyltransferase prevention of apoptosis induced by oxidative stress in endothelial cells
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), IL-12p40, IL-1beta (zeige IL1B Proteine), and resulted in increased expression of the apoptosis initiator caspase-8 (zeige CASP8 Proteine) and bcl2L1.
This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
repression of radiation-induced apoptosis by overexpression of Bcl-xL during embryonic development depends upon the timing of its expression and post-translational events that enable the protein to become effective
The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Delta113p53 functions to antagonize p53 (zeige TP53 Proteine)-induced apoptosis via activating bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
apoptosis regulator Bcl-X
, bcl-2-like protein 1
, protein phosphatase 1, regulatory subunit 52
, B-cell leukemia/lymphoma x
, anti-apoptosis regulatory protein
, B cell lymphoma 2 like
, B cell lymphoma like X
, BCL2-like protein 1
, anti-apoptotic Bcl-xL
, BCLX protein
, BCL2-like 1
, apoptosis regulator R11
, Bcl-xL-like protein 1