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anti-Human AIFM1 Antikörper:
anti-Mouse (Murine) AIFM1 Antikörper:
anti-Rat (Rattus) AIFM1 Antikörper:
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Human Polyclonal AIFM1 Primary Antibody für WB - ABIN222988
Jayanthi, Deng, Noailles, Ladenheim, Cadet: Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004
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Human Polyclonal AIFM1 Primary Antibody für IF (p), IHC (p) - ABIN724010
Gong, Hua, Zhang, Zhao, Tang, Mei, Zhang, Cui, Li: Hypothermia-induced neuroprotection is associated with reduced mitochondrial membrane permeability in a swine model of cardiac arrest. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013
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Human Monoclonal AIFM1 Primary Antibody für ICC, FACS - ABIN968950
Son, Jang, Heo, Chung, Choi, Lee: Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. in Apoptosis : an international journal on programmed cell death 2009
Human Polyclonal AIFM1 Primary Antibody für ELISA, WB - ABIN4278850
Lewis, Wilkinson, Jackson, Mehra, Varambally, Chinnaiyan, Wilkinson: The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. in The Journal of biological chemistry 2012
new form of motor neuropathy expands the phenotypic spectrum of AIFM1 mutations and therefore, the AIFM1 gene should be considered in the diagnosis of hereditary motor neuropathies
X-linked hypomyelination with spondylometaphyseal dysplasia associated with mutations in AIFM1
report of a family carrying a novel missense mutation in AIFM1 that exhibits an isolated axonal polyneuropathy with misassembly of mitochondrial complex I and III.
we sought to investigate mechanisms mediated by Hsp70 (zeige HSP70 Antikörper) acetylation in relation to apoptotic and autophagic programmed cell death. Upon stress-induced apoptosis, Hsp70 (zeige HSP70 Antikörper) acetylation inhibits apoptotic cell death, mediated by Hsp70 (zeige HSP70 Antikörper) association with apoptotic protease-activating factor (Apaf)-1 (zeige APAF1 Antikörper) and apoptosis-inducing factor (AIF), key modulators of caspase (zeige CASP3 Antikörper)-dependent and -independent apoptotic pathways, respectively
Overexpression of full-length AIFM1 suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 (zeige CASP3 Antikörper) and DRAM (zeige DRAM1 Antikörper) are involved in full-length AIFM1-induced apoptosis in HepG2 and Hep3B cells.
Real-time PCR results showed that apoptosis-inducing factor (AIF) and calpain-1 mRNAs were highly expressed in the transitional segmentof the Hirschsprung's disease bowel, whereas autophagy protein 5 (Atg5) was highly expressed in the narrow segment. Western blot results were consistent with mRNA levels, with increased AIF, calpain-1, and Atg5 expressions in the transitional segment compared with the dilated segment.
Data revealed that under a nutrient deficient condition, CD317 (zeige BST2 Antikörper) functions as an anti-apoptotic factor through AIF-mediated caspase (zeige CASP3 Antikörper) and autophagy-independent manner.
we report that AIF-independent PARP-1 (zeige PARP1 Antikörper)-dependent necrosis constitutes a major mechanism of RPE (zeige RPE Antikörper) cell death leading to retinal degeneration in dry age-related macular degeneration .
Downregulation of AIF by hypoxia causes oxidative inactivation of the lipid phosphatase activity of phosphatase and tensin homolog on chromosome 10 (PTEN), with ensuing activation of Akt (zeige AKT1 Antikörper) kinase, phosphorylation of the Akt (zeige AKT1 Antikörper) substrate GSK-3beta and activation of WNT (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling in colon cancer cells.
novel pathway for mda-7/IL-24 (zeige IL24 Antikörper)-induced caspase (zeige CASP3 Antikörper)-independent apoptosis in neuroblastoma (zeige ARHGEF16 Antikörper) cells mediated through modulation of AIF, ATM (zeige ATM Antikörper), and gamma-H2AX (zeige H2AFX Antikörper).
Drosophila Apoptosis-inducing factor (AIF) is a mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.
Mycobacterium bovis-induced macrophage cell death is caspase (zeige CASP3 Antikörper) independent with apoptosis-inducing factor participation.
Mitochondrial apoptosis-inducing factor was found to translocate to the nucleus during porcine epidemic diarrhea virus infection.
caspase-1 (zeige CASP1 Antikörper) regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7 (zeige CASP7 Antikörper)/PARP1 (zeige PARP1 Antikörper)/AIF pathway.
flavonoids of Rosa roxburghii Tratt enhanced radioprotection at least partially by regulating PARP-1 (zeige PARP1 Antikörper)/AIF to reduce apoptosis.
X-ray irradiation induces apoptosis of mouse GC1 sperm cells via nuclear translocation of AIF.
The first structure of a pathogenic AIF variant in complex with NAD+ is reported. The G307E mutation leads to wrong positioning of NAD+ adenylate moiety.
AIF deficiency is a risk factor for the development of diabetic kidney disease.
In conclusion, calpain was involved in oxygen glucose deprivation-induced RGC-5 necroptosis with the increased expression of its downstream molecule tAIF.
The results identify new protein-protein interactions between AIF-Cx43 (zeige GJA1 Antikörper), ETFB (zeige ETFB Antikörper)-Cx43 (zeige GJA1 Antikörper) and AIF-ETFB (zeige ETFB Antikörper) as possible players in the regulation of the mitochondrial redox state.
our findings suggest that MIA40 (zeige CHCHD4 Antikörper) reduction contributes to the effects of AIF deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits.
These results indicate that the adenylate moiety of NAD(+)/H is crucial for the association with AIF and for the subsequent structural reorganization of the complex, but not for protein dimerization.
Taken together, these data suggest that AIF is likely to play a region-specific role in AD-related caspase (zeige CASP3 Antikörper)-independent PCD (zeige PCBD1 Antikörper), which is consistent with aging-associated mitochondrial impairment and oxidative stress.
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
apoptosis-inducing factor 1, mitochondrial
, programmed cell death 8 (apoptosis-inducing factor)
, striatal apoptosis-inducing factor
, apoptosis inducing factor
, programmed cell death 8
, apoptosis-inducing factor, mitochondrion-associated, 1
, mammary apoptosis inducing factor
, flavoprotein and apoptosis inductor
, apoptosis-inducing factor 1, mitochondrial-like
, programmed cell death protein 8