NCK1 Antikörper

Produktnummer ABIN969545

Der Maus Monoklonal Anti-NCK1-Antikörper wurde für WB, IHC, ELISA und FACS validiert. Er ist geeignet, NCK1 in Proben von Human und Affe zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für NCK1 Antikörper (ABIN969545)

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon: 5B7

Produktdetails anti-NCK1 Antikörper

Verwendungszweck: NCK1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human NCK1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-NCK1 Antikörper (ABIN969545)

Preisinger, Kolch: "The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway." in: Cellular signalling, Vol. 22, Issue 5, pp. 848-56, (2010) (PubMed).

Blasutig, New, Thanabalasuriar, Dayarathna, Goudreault, Quaggin, Li, Gruenheid, Jones, Pawson: "Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization." in: Molecular and cellular biology, Vol. 28, Issue 6, pp. 2035-46, (2008) (PubMed).

Details zu NCK1

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Andere Bezeichnung: NCK1

Hintergrund: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

Molekulargewicht: 47 kDa

UniProt: P16333

Pathways: T-Zell Rezeptor Signalweg, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals