Hexosaminidase A Antikörper

Produktnummer ABIN969526

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Hexosaminidase A in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für Hexosaminidase A Antikörper (ABIN969526)

Target: Hexosaminidase A (HEXA)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Hexosaminidase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: 3F10

Produktdetails anti-Hexosaminidase A Antikörper

Verwendungszweck: HEXA Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human HEXA expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Hexosaminidase A Antikörper (ABIN969526)

Park, Morgan, Sharma, Li, Lobo, Redman, Salazar, Sun, Neidich, Strom: "Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis." in: Pediatric research, Vol. 67, Issue 2, pp. 217-20, (2010) (PubMed).

Olszewska, Borzym-Kluczyk, Rzewnicki, Rutkowska, Knas, Rogowski, Waniewska, Wielgosz: "Hexosaminidase as a new potential marker for larynx cancer." in: Clinical biochemistry, Vol. 42, Issue 10-11, pp. 1187-9, (2009) (PubMed).

Details zu Hexosaminidase A

Target: Hexosaminidase A (HEXA)

Andere Bezeichnung: HEXA

Hintergrund: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Molekulargewicht: 60.7 kDa

UniProt: P06865

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process