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Hexosaminidase A Antikörper

Dieses Mouse Monoclonal-Antikörper erkennt spezifisch Hexosaminidase A in WB, ELISA, FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN969526

Kurzübersicht für Hexosaminidase A Antikörper (ABIN969526)

Target

Alle Hexosaminidase A (HEXA) Antikörper anzeigen
Hexosaminidase A (HEXA)

Reaktivität

  • 61
  • 27
  • 15
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 53
  • 14
Maus

Klonalität

  • 55
  • 12
Monoklonal

Konjugat

  • 46
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Hexosaminidase A Antikörper ist unkonjugiert

Applikation

  • 55
  • 33
  • 19
  • 8
  • 8
  • 7
  • 6
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon

3F10
  • Verwendungszweck

    HEXA Antibody

    Aufreinigung

    Purified antibody

    Immunogen

    Purified recombinant fragment of human HEXA expressed in E. Coli.

    Isotyp

    IgG2b
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Park, Morgan, Sharma, Li, Lobo, Redman, Salazar, Sun, Neidich, Strom: "Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis." in: Pediatric research, Vol. 67, Issue 2, pp. 217-20, (2010) (PubMed).

    Olszewska, Borzym-Kluczyk, Rzewnicki, Rutkowska, Knas, Rogowski, Waniewska, Wielgosz: "Hexosaminidase as a new potential marker for larynx cancer." in: Clinical biochemistry, Vol. 42, Issue 10-11, pp. 1187-9, (2009) (PubMed).

  • Target

    Hexosaminidase A (HEXA)

    Andere Bezeichnung

    HEXA

    Hintergrund

    This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

    Molekulargewicht

    60.7 kDa

    UniProt

    P06865

    Pathways

    Sensory Perception of Sound, Glycosaminoglycan Metabolic Process
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