ALPL Antikörper

Produktnummer ABIN969500

Der Maus Monoklonal Anti-ALPL-Antikörper wurde für WB, ELISA, IHC und FACS validiert. Er ist geeignet, ALPL in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für ALPL Antikörper (ABIN969500)

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: 2F4

Produktdetails anti-ALPL Antikörper

Verwendungszweck: ALPL Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ALPL expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-ALPL Antikörper (ABIN969500)

Kannampuzha, Tupy, Pritzker: "Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution." in: The Journal of rheumatology, Vol. 36, Issue 12, pp. 2758-65, (2009) (PubMed).

Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes." in: Calcified tissue international, Vol. 85, Issue 3, pp. 228-34, (2009) (PubMed).

Details zu ALPL

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Andere Bezeichnung: ALPL

Hintergrund: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Molekulargewicht: 57.3 kDa

Gen-ID: 249

UniProt: P05186