Reticulon 3 Antikörper

Produktnummer ABIN969388

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Reticulon 3 in ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für Reticulon 3 Antikörper (ABIN969388)

Target: Reticulon 3 (RTN3)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Reticulon 3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Klon: 1E11

Produktdetails anti-Reticulon 3 Antikörper

Verwendungszweck: RTN3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of RTN3 expressed in E. Coli.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Reticulon 3 Antikörper (ABIN969388)

Kim, Chai, Ryu: "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion." in: Biochemical and biophysical research communications, Vol. 330, Issue 4, pp. 1095-102, (2005) (PubMed).

Cai, Saiyin, Lin, Zhang, Tang, Pan, Yu: "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain." in: Brain research. Molecular brain research, Vol. 138, Issue 2, pp. 236-43, (2005) (PubMed).

Wakana, Koyama, Nakajima, Hatsuzawa, Nagahama, Tani, Hauri, Melançon, Tagaya: "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi." in: Biochemical and biophysical research communications, Vol. 334, Issue 4, pp. 1198-205, (2005) (PubMed).

Oertle, Klinger, Stuermer, Schwab: "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 10, pp. 1238-47, (2003) (PubMed).

Details zu Reticulon 3

Target: Reticulon 3 (RTN3)

Andere Bezeichnung: RTN3

Hintergrund: RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

Molekulargewicht: 113 kDa

UniProt: O95197