Dieses Maus Monoklonal-Antikörper erkennt spezifisch PTK6 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Park, Lee, Lee: "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG." in: Journal of biochemistry, Vol. 119, Issue 2, pp. 235-9, (1997) (PubMed).
Target
PTK6
(PTK6 Protein tyrosine Kinase 6 (PTK6))
Andere Bezeichnung
PTK6
Hintergrund
PTK6 (protein tyrosine kinase 6, BRK or FLJ42088), with 451-amino acid protein (about 52 kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.