PROZ Antikörper

Produktnummer ABIN969368

Der Maus Monoklonal Anti-PROZ-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, PROZ in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PROZ Antikörper (ABIN969368)

Target: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PROZ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 2B4

Produktdetails anti-PROZ Antikörper

Verwendungszweck: PROZ Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of PROZ expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PROZ Antikörper (ABIN969368)

Blyth, Favaloro, Harris, Kairaitis: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).

Paidas, Ku, Lee, Manish, Thurston, Lockwood, Arkel: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." in: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).

Details zu PROZ

Target: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Andere Bezeichnung: PROZ

Hintergrund: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Molekulargewicht: 45 kDa

Gen-ID: 8858

UniProt: P22891