Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PROZ Antikörper

Der Maus Monoklonal Anti-PROZ-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, PROZ in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN969368

Kurzübersicht für PROZ Antikörper (ABIN969368)

Target

Alle PROZ Antikörper anzeigen
PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Reaktivität

  • 34
  • 4
  • 1
Human

Wirt

  • 31
  • 6
  • 1
Maus

Klonalität

  • 34
  • 4
Monoklonal

Konjugat

  • 19
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PROZ Antikörper ist unkonjugiert

Applikation

  • 32
  • 13
  • 11
  • 9
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
Western Blotting (WB), ELISA

Klon

2B4
  • Verwendungszweck

    PROZ Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of PROZ expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Blyth, Favaloro, Harris, Kairaitis: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).

    Paidas, Ku, Lee, Manish, Thurston, Lockwood, Arkel: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." in: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).

  • Target

    PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

    Andere Bezeichnung

    PROZ

    Hintergrund

    PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

    Molekulargewicht

    45 kDa

    Gen-ID

    8858

    UniProt

    P22891
Sie sind hier:
Chat with us!