Prohibitin Antikörper

Produktnummer ABIN969353

Der Maus Monoklonal Anti-Prohibitin-Antikörper wurde für WB, IHC, ELISA, FACS und ICC validiert. Er ist geeignet, Prohibitin in Proben von Human, Maus, Ratte und Affe zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Prohibitin Antikörper (ABIN969353)

Target: Prohibitin (PHB)

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Prohibitin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 5H7

Produktdetails anti-Prohibitin Antikörper

Verwendungszweck: PHB Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human PHB expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Prohibitin Antikörper (ABIN969353)

Shi, Li, Liu, Xu, Tang, Liang, Zhao, Yang: "Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT)." in: Journal of cellular biochemistry, Vol. 108, Issue 4, pp. 926-34, (2009) (PubMed).

Ande, Mishra: "Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signaling." in: Biochemical and biophysical research communications, Vol. 390, Issue 3, pp. 1023-8, (2009) (PubMed).

Details zu Prohibitin

Target: Prohibitin (PHB)

Andere Bezeichnung: PHB

Hintergrund: Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Molekulargewicht: 30 kDa

Gen-ID: 5245

UniProt: P35232

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling