MSI2 Antikörper

Produktnummer ABIN969295

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MSI2 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für MSI2 Antikörper (ABIN969295)

Target: MSI2 (Musashi Homolog 2 (MSI2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MSI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: 2C11

Produktdetails anti-MSI2 Antikörper

Verwendungszweck: MSI2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MSI2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MSI2 Antikörper (ABIN969295)

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

De Weer, Speleman, Cauwelier, Van Roy, Yigit, Verhasselt, De Moerloose, Benoit, Noens, Selleslag, Lippert, Struski, Bastard, De Paepe, Vandenberghe, Hagemeijer, Dastugue, Poppe: "EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22." in: Haematologica, Vol. 93, Issue 12, pp. 1903-7, (2008) (PubMed).

Details zu MSI2

Target: MSI2 (Musashi Homolog 2 (MSI2))

Andere Bezeichnung: MSI2

Hintergrund: Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous, detected at low levels.

Molekulargewicht: 35 kDa

UniProt: Q96DH6