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IHOG Antikörper

IHOG Reaktivität: Drosophila melanogaster ELISA, WB Wirt: Maus Monoclonal 3G8 unconjugated
Produktnummer ABIN969211
  • Target Alle IHOG Produkte
    IHOG (Interference Hedgehog (IHOG))
    Reaktivität
    Drosophila melanogaster
    Wirt
    Maus
    Klonalität
    Monoklonal
    Applikation
    ELISA, Western Blotting (WB)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human IHOG expressed in E. coli.
    Klon
    3G8
    Isotyp
    IgG1
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • McLellan, Yao, Zheng, Geisbrecht, Ghirlando, Beachy, Leahy: "Structure of a heparin-dependent complex of Hedgehog and Ihog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).

  • Target
    IHOG (Interference Hedgehog (IHOG))
    Andere Bezeichnung
    IHOG
    Synonyme
    CG9211 antikoerper, CT26314 antikoerper, Dmel\\CG9211 antikoerper, Ihog antikoerper, iHog antikoerper, interference hedgehog antikoerper, ihog antikoerper
    Hintergrund

    Description: The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

    Aliases: CG9211, CT26314, Dmel\CG9211, ihog, Ihog

    Molekulargewicht
    98 kDa
    Gen-ID
    33972
    HGNC
    33972
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