IHOG Antikörper

Produktnummer ABIN969211

Dieses Maus Monoklonal-Antikörper erkennt spezifisch IHOG in ELISA. Er zeigt eine Reaktivität gegenüber Drosophila melanogaster und wurde in 1 Publikation erwähnt.

Kurzübersicht für IHOG Antikörper (ABIN969211)

Target: IHOG (Interference Hedgehog (IHOG))

Reaktivität: Drosophila melanogaster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IHOG Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 3G8

Produktdetails anti-IHOG Antikörper

Verwendungszweck: IHOG Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human IHOG expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-IHOG Antikörper (ABIN969211)

McLellan, Yao, Zheng, Geisbrecht, Ghirlando, Beachy, Leahy: "Structure of a heparin-dependent complex of Hedgehog and Ihog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).

Details zu IHOG

Target: IHOG (Interference Hedgehog (IHOG))

Andere Bezeichnung: IHOG

Hintergrund: The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

Molekulargewicht: 98 kDa

Gen-ID: 33972

UniProt: Q9VM64