IGF1R-beta (AA 1101-1367) Antikörper

Produktnummer ABIN969207

Produktdetails

Target: IGF1R-beta

Bindungsspezifität: AA 1101-1367

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Verwendungszweck: IGF1R-Beta Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.

Klon: 3G5C1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen

Zhu, Jiang, Thompson: "Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas." in: Carcinogenesis, Vol. 24, Issue 7, pp. 1225-31, (2003) (PubMed).

Ling, Maile, Clemmons et al.: "Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth ..." in: Molecular endocrinology (Baltimore, Md.), Vol. 17, Issue 9, pp. 1824-33, (2003) (PubMed).

Antigendetails

Target: IGF1R-beta

Hintergrund:

Description: IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Aliases: IGF1R

Molekulargewicht: 96kDa

Gen-ID: 3480

HGNC: 3480

UniProt: P08069