FOXP3 Antikörper

Produktnummer ABIN969156

Dieses Anti-FOXP3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FOXP3 in ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für FOXP3 Antikörper (ABIN969156)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 4C7

Produktdetails anti-FOXP3 Antikörper

Verwendungszweck: FOXP3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXP3 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-FOXP3 Antikörper (ABIN969156)

Yuan, Chen, Li, Dong, Xue, Wang, Zhang, Wang, Zhang, Ge, Shen, Xu: "Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." in: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).

Sarigul, Yazisiz, Bassorgun, Ulker, Avci, Erbasan, Gelen, Gorczynski, Terzioglu: "The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome." in: Lupus, Vol. 19, Issue 2, pp. 138-45, (2010) (PubMed).

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3

Hintergrund: FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

Molekulargewicht: 47.2 kDa

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation