FOXD3 Antikörper

Produktnummer ABIN969152

Es gibt 1 Publikation für dieses Produkt. Der Maus Monoklonal anti-FOXD3 Antikörper wird verwendet zum Nachweis von FOXD3 in Proben von Human, Maus und Affe. Er wurde validiert für WB und ELISA.

Kurzübersicht für FOXD3 Antikörper (ABIN969152)

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 5G9

Produktdetails anti-FOXD3 Antikörper

Verwendungszweck: FOXD3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-FOXD3 Antikörper (ABIN969152)

Saleem, Banerjee-Basu, Berry, Baxevanis, Walter: "Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).

Details zu FOXD3

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Andere Bezeichnung: FOXD3

Hintergrund: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

Molekulargewicht: 48 kDa

UniProt: Q9UJU5