Estrogen Receptor alpha Antikörper

Produktnummer ABIN969119

Der Maus Monoklonal Anti-Estrogen Receptor alpha-Antikörper wurde für WB, IHC, ELISA und ICC validiert. Er ist geeignet, Estrogen Receptor alpha in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Estrogen Receptor alpha Antikörper (ABIN969119)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Klon: 6B6

Produktdetails anti-Estrogen Receptor alpha Antikörper

Verwendungszweck: ESR1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human ESR1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Estrogen Receptor alpha Antikörper (ABIN969119)

Deegan, Seldeen, McDonald, Bhat, Farooq: "Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake." in: Biochemistry, Vol. 49, Issue 29, pp. 5978-88, (2010) (PubMed).

Harsløf, Husted, Carstens, Stenkjaer, Langdahl: "Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis." in: Calcified tissue international, Vol. 87, Issue 1, pp. 25-35, (2010) (PubMed).

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: ESR1

Hintergrund: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Molekulargewicht: 66 kDa

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly