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CTCF Antikörper

Der Maus Monoklonal Anti-CTCF-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CTCF in Proben von Human und Affe zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN969071

Kurzübersicht für CTCF Antikörper (ABIN969071)

Target

Alle CTCF Antikörper anzeigen
CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Reaktivität

  • 52
  • 35
  • 31
  • 8
  • 8
  • 7
  • 7
  • 5
  • 5
  • 4
  • 4
  • 2
  • 1
  • 1
Human, Affe

Wirt

  • 45
  • 6
  • 2
  • 1
  • 1
Maus

Klonalität

  • 34
  • 21
Monoklonal

Konjugat

  • 41
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser CTCF Antikörper ist unkonjugiert

Applikation

  • 35
  • 13
  • 13
  • 11
  • 10
  • 6
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA

Klon

1D11
  • Verwendungszweck

    CTCF Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human CTCF expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: "Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma." in: Journal of molecular medicine (Berlin, Germany), Vol. 86, Issue 9, pp. 1057-66, (2008) (PubMed).

    Majumder, Gomez, Chadwick, Boss: "The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions." in: The Journal of experimental medicine, Vol. 205, Issue 4, pp. 785-98, (2008) (PubMed).

    Stedman, Kang, Lin, Kissil, Bartolomei, Lieberman: "Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators." in: The EMBO journal, Vol. 27, Issue 4, pp. 654-66, (2008) (PubMed).

  • Target

    CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

    Andere Bezeichnung

    CTCF

    Hintergrund

    This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

    Molekulargewicht

    83 kDa

    UniProt

    P49711
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