BPTF Antikörper

Produktnummer ABIN968990

Der Maus Monoklonal Anti-BPTF-Antikörper wurde für ELISA validiert. Er ist geeignet, BPTF in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für BPTF Antikörper (ABIN968990)

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BPTF Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 2F10

Produktdetails anti-BPTF Antikörper

Verwendungszweck: BPTF Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human BPTF expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-BPTF Antikörper (ABIN968990)

Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).

Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).

Details zu BPTF

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Andere Bezeichnung: BPTF

Hintergrund: BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level) .Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

Molekulargewicht: 338 kDa

Gen-ID: 2186

UniProt: Q12830