BMX Antikörper

Produktnummer ABIN968989

Produktdetails anti-BMX Antikörper

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BMX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human BMX expressed in E. coli.

Klon: 1C6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-BMX Antikörper (ABIN968989)

Palmer, Mutch, Workman, McDaid, Horwood, Foxwell: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, (2008) (PubMed).

Côté, Motoyama, Bush, Vuori: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, (2005) (PubMed).

Details zu BMX

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Andere Bezeichnung: BMX (BMX Produkte)

Synonyme: BMX antikoerper, ETK antikoerper, PSCTK2 antikoerper, PSCTK3 antikoerper, Etk antikoerper, Etk/Bmx antikoerper, Tyro8 antikoerper, RGD1565643 antikoerper, BMX non-receptor tyrosine kinase antikoerper, BMX antikoerper, bmx antikoerper, Bmx antikoerper

Hintergrund:

Description: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Aliases: ETK, PSCTK2, PSCTK3, BMX

Molekulargewicht: 78 kDa

Gen-ID: 660

HGNC: 660