ALDH1A1 Antikörper

Produktnummer ABIN968955

Produktdetails anti-ALDH1A1 Antikörper

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALDH1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human ALDH1A1 expressed in E. coli.

Klon: 5A11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-ALDH1A1 Antikörper (ABIN968955)

Zhang, Shoeb, Goswamy, Liu, Xiao, Hogan, Campbell, Ansari: "Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells." in: Journal of neuroscience research, Vol. 88, Issue 3, pp. 686-94, (2010) (PubMed).

Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, (2009) (PubMed).

Low, Kiyotani, Mushiroda, Daigo, Nakamura, Zembutsu: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients." in: Journal of human genetics, Vol. 54, Issue 10, pp. 564-71, (2009) (PubMed).

Details zu ALDH1A1

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Andere Bezeichnung: ALDH1A1 (ALDH1A1 Produkte)

Synonyme: ALDC antikoerper, ALDH-E1 antikoerper, ALDH1 antikoerper, ALDH11 antikoerper, PUMB1 antikoerper, RALDH1 antikoerper, AL1A1 antikoerper, aldc antikoerper, aldh-e1 antikoerper, aldh1 antikoerper, aldh11 antikoerper, pumb1 antikoerper, raldh1 antikoerper, GGADHR antikoerper, ALDH1A1 antikoerper, ALDDH antikoerper, Ahd2 antikoerper, Aldh1 antikoerper, Aldh2 antikoerper, Ahd-2 antikoerper, Aldh1a2 antikoerper, E1 antikoerper, Raldh1 antikoerper, Aldh1a1 antikoerper, ALHDII antikoerper, RALDH 1 antikoerper, RalDH1 antikoerper, aldehyde dehydrogenase 1 family member A1 antikoerper, aldehyde dehydrogenase 1 family, member A1 antikoerper, aldehyde dehydrogenase 1 family member A1 L homeolog antikoerper, aldehyde dehydrogenase family 1, subfamily A1 antikoerper, aldehyde dehydrogenase antikoerper, retinal dehydrogenase 1 antikoerper, ALDH1A1 antikoerper, aldh1a1 antikoerper, Aldh1a1 antikoerper, aldh1a1.L antikoerper, aldH1 antikoerper, LOC100732581 antikoerper, LOC101822890 antikoerper

Hintergrund:

Description: ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum, this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.

Aliases: ALDC, ALDH1, PUMB1, ALDH11, RALDH1, ALDH-E1, MGC2318, ALDH1A1

Molekulargewicht: 55 kDa

Gen-ID: 216

HGNC: 216

Pathways: Dopaminergic Neurogenesis