EZH2 Antikörper (AA 156-256)

Produktnummer ABIN968906

Der Maus Monoklonal Anti-EZH2-Antikörper wurde für WB und IF validiert. Er ist geeignet, EZH2 in Proben von Human, Maus, Ratte, Hund und Huhn zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für EZH2 Antikörper (AA 156-256) (ABIN968906)

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EZH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 11-EZH2

Produktdetails anti-EZH2 Antikörper

Bindungsspezifität: AA 156-256

Kreuzreaktivität: Hund, Ratte (Rattus), Maus, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human EZH2 recombinant protein aa. 156-256

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968537, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-EZH2 Antikörper (ABIN968906)

Raaphorst, Otte, van Kemenade, Blokzijl, Fieret, Hamer, Satijn, Meijer: "Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 5925-34, (2001) (PubMed).

van Kemenade, Raaphorst, Blokzijl, Fieret, Hamer, Satijn, Otte, Meijer: "Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma." in: Blood, Vol. 97, Issue 12, pp. 3896-901, (2001) (PubMed).

Details zu EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Andere Bezeichnung: EZH2

Hintergrund: The Polycomb group (PcG) of gene products are essential for the maintenance, but not initiation, of the transcriptionally repressed state of development genes. Those genes encode a structurally diverse group of proteins with conserved functions from flies to human cells and from complexes as a result of mutual associations ultimately influencing gene expression. EZH2 is a human homologue of Drosophil's Enhancer of Zeste gene, an important regulator of homeobox gene expression. The expression of EZH2 was seen in follicular T cells and at different stages during T-cell differentiation. Additionally, in lymphocytes, EZH2 interacts with the signal transduction protein Vav and is highly expressed in a variety of tumors such as lymphoma and prostate. The predicted molecular weight for this protein is approximately 85 kDa (SwissProt:Q15910).

Molekulargewicht: 91 kDa

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation