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Sortilin 1 Antikörper (AA 300-422)

Der Maus Monoklonal Anti-Sortilin 1-Antikörper wurde für WB und IF validiert. Er ist geeignet, Sortilin 1 in Proben von Human, Ratte, Maus, Hund und Huhn zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN968738

Kurzübersicht für Sortilin 1 Antikörper (AA 300-422) (ABIN968738)

Target

Alle Sortilin 1 (SORT1) Antikörper anzeigen
Sortilin 1 (SORT1)

Reaktivität

  • 52
  • 36
  • 30
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus, Hund, Huhn

Wirt

  • 51
  • 7
  • 2
Maus

Klonalität

  • 51
  • 9
Monoklonal

Konjugat

  • 30
  • 6
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Sortilin 1 Antikörper ist unkonjugiert

Applikation

  • 43
  • 19
  • 19
  • 16
  • 13
  • 13
  • 7
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)

Klon

48-Neurotensin Receptor 3
  • Bindungsspezifität

    • 16
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 300-422

    Kreuzreaktivität

    Maus, Ratte (Rattus), Hund, Huhn

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Human Neurotensin Receptor 3 aa. 300-422

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN968700, ABIN967389

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20°C.
  • Nielsen, Jacobsen, Olivecrona, Gliemann, Petersen: "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8832-6, (1999) (PubMed).

    Mazella, Zsürger, Navarro, Chabry, Kaghad, Caput, Ferrara, Vita, Gully, Maffrand, Vincent: "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26273-6, (1998) (PubMed).

    Morris, Ross, Lane, Moestrup, Petersen, Keller, Lienhard: "Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes." in: The Journal of biological chemistry, Vol. 273, Issue 6, pp. 3582-7, (1998) (PubMed).

  • Target

    Sortilin 1 (SORT1)

    Andere Bezeichnung

    Neurotensin Receptor 3

    Hintergrund

    Neurotensin (NT) is a neuropeptide that modulates dopaminergic transmission, triggers analgesic responses, induces hypotension, decreases gastric acid secretion, and activates lipid digestion. NT is a ligand for NT receptors, which include both G-protein coupled and non-G-protein coupled receptors. Neurotensin Receptor 3 (NTR3) is a non-G-protein coupled receptor that has a lumenal domain homologous to sorting proteins, and a short cytoplasmic tail homologous to mannose-6-phosphate/IGF-II receptor. NTR3 was also identified as sortilin/gp95, a component of GLUT4 vesicles in adipocytes that has been implicated in lipoprotein lipase degradation. NTR3 mRNA is expressed in brain, skeletal muscle, heart, and adipocytes. NTR3 mature protein has 44 N-terminal amino acid residues cleaved off, which may facilitate ligand binding to the receptor. Cellular localization of NTR3 is in the Golgi compartment and vesicles, as well as on the cell surface. In addition to roles in neuropeptide and lipoprotein degradation, NTR3 may also be involved in receptor protein sorting. Thus, NTR3 is a multifunctional transmembrane protein that acts as both a intracellular sorting receptor and extracellular ligand-binding receptor.
    Synonyms: NTR3

    Molekulargewicht

    95 kDa

    Pathways

    Neurotrophin Signalübertragung
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