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DLC1 Antikörper (AA 47-249)

DLC1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 3-DLC unconjugated
Produktnummer ABIN968714
  • Target Alle DLC1 Antikörper anzeigen
    DLC1 (Deleted in Liver Cancer 1 (DLC1))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 47-249
    Reaktivität
    • 38
    • 9
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 36
    • 3
    • 1
    Maus
    Klonalität
    • 39
    • 1
    Monoklonal
    Konjugat
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DLC1 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 13
    • 11
    • 10
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Please refer to us for technical protocols.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human DLC-1 aa. 47-249
    Klon
    3-DLC
    Isotyp
    IgG1
    Top Product
    Discover our top product DLC1 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Sekimata, Kabuyama, Emori, Homma: "Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17757-62, (1999) (PubMed).

    Yuan, Miller, Keck, Zimonjic, Thorgeirsson, Popescu: "Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP." in: Cancer research, Vol. 58, Issue 10, pp. 2196-9, (1998) (PubMed).

    Homma, Emori: "A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities." in: The EMBO journal, Vol. 14, Issue 2, pp. 286-91, (1995) (PubMed).

  • Target
    DLC1 (Deleted in Liver Cancer 1 (DLC1))
    Andere Bezeichnung
    DLC-1 (DLC1 Produkte)
    Synonyme
    ARHGAP7 antikoerper, HP antikoerper, STARD12 antikoerper, p122-RhoGAP antikoerper, rhogap7 antikoerper, DLC-1 antikoerper, StARD12 antikoerper, Dlc-1 antikoerper, A730069N07Rik antikoerper, Arhgap7 antikoerper, dlc-1 antikoerper, RhoGAP antikoerper, Dlc1 antikoerper, DLC1 Rho GTPase activating protein antikoerper, DLC1 Rho GTPase activating protein S homeolog antikoerper, rho GTPase-activating protein 7 antikoerper, deleted in liver cancer 1 antikoerper, DLC1 antikoerper, dlc1.S antikoerper, dlc1 antikoerper, LOC100456847 antikoerper, Dlc1 antikoerper, LOC100729904 antikoerper
    Hintergrund
    Members of the Ras superfamily of GTPases are distantly related to the heterotrimeric G proteins and shuttle between inactive and active GTP-bound forms. Conversion between these forms is controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho is a GTPase that regulates cell morphology and motility in response to extracellular signals. p190A, p190B, and p122 RhoGAPs all contain RhoGAP domains and regulate the GTPase activity of Rho. p122 RhoGAP exhibits GAP activity for RhoA, but not Rac1, and binds and activates PLC-delta1. Microinjection of p122 RhoGAP suppresses LPA-induced formation of stress fibers and focal adhesions. Deleted in liver cancer-1 (DLC-1) was identified by its frequent deletion in liver cancer and is a human homologue of rat p122 RhoGAP. DLC-1 is expressed in many hepatocellular carcinoma tissues and cell lines and could be an important tumor suppressor gene. In normal human tissues, DLC-1 is expressed widely with the highest expression in heart and lung. Both p122 RhoGAP and DLC-1 have RhoGAP domains toward their C-terminal regions, which is thought to be important for regulation of Rho GTPase activity in many tissues. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    123 kDa
    Pathways
    Tube Formation, Positive Regulation of Endopeptidase Activity
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