NUP88 Antikörper (AA 314-425)

Produktnummer ABIN968699

Der Maus Monoklonal Anti-NUP88-Antikörper wurde für WB und IF validiert. Er ist geeignet, NUP88 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für NUP88 Antikörper (AA 314-425) (ABIN968699)

Target: NUP88 (Nucleoporin 88kDa (NUP88))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUP88 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 22-Nup88

Produktdetails anti-NUP88 Antikörper

Bindungsspezifität: AA 314-425

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Nup88 aa. 314-425

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-NUP88 Antikörper (ABIN968699)

Martínez, Alonso, Moragues, Pontón, Schneider: "The nuclear pore complex protein Nup88 is overexpressed in tumor cells." in: Cancer research, Vol. 59, Issue 21, pp. 5408-11, (1999) (PubMed).

Bastos, Ribas de Pouplana, Enarson, Bodoor, Burke: "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex." in: The Journal of cell biology, Vol. 137, Issue 5, pp. 989-1000, (1997) (PubMed).

Fornerod, van Deursen, van Baal, Reynolds, Davis, Murti, Fransen, Grosveld: "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88." in: The EMBO journal, Vol. 16, Issue 4, pp. 807-16, (1997) (PubMed).

Details zu NUP88

Target: NUP88 (Nucleoporin 88kDa (NUP88))

Andere Bezeichnung: Nup88

Hintergrund: Nucleocytoplasmic transport involves the binding and interaction of several cytosolic and nuclear pore proteins by at least two different mechanisms. One mechanism is mediated by karyopherins to transport proteins with the nuclear localization sequence (NLS) and an alternative pathway uses the protein Transportin. Morphologically both pathways require the use of the nuclear pore complex (NPC) which acts as a gate mediating active transport of proteins and RNA into and out of the nucleus. The NLS binds to karyopherin alpha, and to the N-terminal region of karyopherin beta. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. p62 is the best characterized member of a group of nucleoporins that line the central region of the NPC. A tightly associated complex is formed by p62 and two other nucleoporins, p54 and p58. Nup88 is a nonglycosylated nucleoporin, that does not contain the characteristic GLFG or XFXFG repeats found in other NPC proteins. The structure of Nup88 includes a coiled-coil domain required for association with the NPC. Nup88 is overexpressed during oncogenesis and development, and forms a complex with the nuclear transport factors, Exportin-1 and Nup214.

Molekulargewicht: 88 kDa

Pathways: SARS-CoV-2 Protein Interaktom