Density Regulated Protein Antikörper (AA 19-201)

Produktnummer ABIN968651

Der Maus Monoklonal Anti-Density Regulated Protein-Antikörper wurde für WB und IF validiert. Er ist geeignet, Density Regulated Protein in Proben von Human, Maus, Ratte und Hund zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Density Regulated Protein Antikörper (AA 19-201) (ABIN968651)

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Density Regulated Protein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 22-Drp1

Produktdetails anti-Density Regulated Protein Antikörper

Bindungsspezifität: AA 19-201

Kreuzreaktivität: Maus, Ratte (Rattus), Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Drp1 aa. 19-201

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968551, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Density Regulated Protein Antikörper (ABIN968651)

Deyo, Chiao, Tainsky: "drp, a novel protein expressed at high cell density but not during growth arrest." in: DNA and cell biology, Vol. 17, Issue 5, pp. 437-47, (1998) (PubMed).

Details zu Density Regulated Protein

Target: Density Regulated Protein (DENR) (Density-Regulated Protein (DENR))

Andere Bezeichnung: Density-regulated protein

Hintergrund: In culture, cell density can have profound effects on gene expression, enzymatic activity, and cell signaling pathways. Using differential screening of cDNAs from low-passage nontumorigenic teratocarcinoma cells versus high passage tumorigenic cells, a protein was identified that is regulated in cell-density dependent manner. This protein, density-regulated protein 1 (drp1), contains putative sites for N-myristoylation and phosphorylation sites for cAMP and/or cGMP-dependent kinase, casein kinase II, and PKC. The expression of drp1 is enriched in high density cultures of both nontumorigenic and tumorigenic cell lines and is widely detected in adult organs, especially skeletal and cardiac muscle. In addition, increased expression of drp1 is not due to growth arrest as a result of serum starvation or TGF-beta treatment nor is it a result of factors found in the media of high density cultures. Interestingly, drp1 is expressed highest in skeletal and cardiac muscle where unique cell-cell contacts are involved in muscle cell membrane depolarization and contraction. Thus, drp1 expression may be regulated by signaling pathways related to specific types of cell-cell contacts. This antibody is routinely tested by western blot analysis.
Synonyms: Density Regulated Protein-1

Molekulargewicht: 27 kDa