Doublecortin Antikörper (AA 211-317)

Produktnummer ABIN968637

Dieses Anti-Doublecortin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Doublecortin in WB und IF. Geeignet für Maus. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für Doublecortin Antikörper (AA 211-317) (ABIN968637)

Target: Doublecortin (DCX)

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Doublecortin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 30-Doublecortin

Produktdetails anti-Doublecortin Antikörper

Bindungsspezifität: AA 211-317

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Doublecortin aa. 211-317

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Doublecortin Antikörper (ABIN968637)

Magavi, Leavitt, Macklis: "Induction of neurogenesis in the neocortex of adult mice." in: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).

des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." in: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).

Gleeson, Allen, Fox, Lamperti, Berkovic, Scheffer, Cooper, Dobyns, Minnerath, Ross, Walsh: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." in: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).

Details zu Doublecortin

Target: Doublecortin (DCX)

Andere Bezeichnung: Doublecortin

Hintergrund: The cerebral cortex is composed of multiple layers of neurons of distinct types and functions, which perform in unison to orchestrate cognitive function. The formation of the cortex relies on complex signaling mechanisms, which mediate the migration of newly formed neurons from deep within the brain to the superficial regions. Defects in neuronal migration and disruption of the multi-layered cortex are apparent in conditions such as X-linked lissencephaly (XLIS) and subcortical laminar heterotopia (SCLH) or double cortex (DC) syndrome. Mutations in the doublecortin gene have been linked to these brain disorders. Doublecortin is highly expressed in developing brain, primarily in migrating neurons. It is significantly homologous with the N-terminal region of the product of the KIAA0369 gene, a protein that is also similar to the CaM kinase family in its C-terminal region. Doublecortin has four potential MAP kinase family phosphorylation sites and a putative site for Abl tyrosine phosphorylation. Thus, doublecortin is thought to be an integral component of tyrosine kinase signal transduction pathways that regulate neuronal migration and development of the cerebral cortex.

Molekulargewicht: 41 kDa