ICAM1 Antikörper (AA 46-160)

Produktnummer ABIN968635

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ICAM1 in WB und FM. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für ICAM1 Antikörper (AA 46-160) (ABIN968635)

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Fluorescence Microscopy (FM)

Klon: 28-CD54

Produktdetails anti-ICAM1 Antikörper

Bindungsspezifität: AA 46-160

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CD54/ICAM-1 aa. 46-160

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-ICAM1 Antikörper (ABIN968635)

Wang, Doerschuk: "Neutrophil-induced changes in the biomechanical properties of endothelial cells: roles of ICAM-1 and reactive oxygen species." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 12, pp. 6487-94, (2000) (PubMed).

Details zu ICAM1

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Andere Bezeichnung: CD54 (ICAM-1)

Hintergrund: The migration of T cells through lymph nodes and their interactions with antigen presenting cells (APCs) involve adhesion molecules on the surfaces of the T cell and the cell with which it interacts. These molecules include the selectins, the integrins, members of the immunoglobulin superfamily, and some mucin-like proteins. The integrins mediate adhesion between cells and between cells and the extracellular matrix. LFA-1 (lymphocyte function-associated antigen 1), a member of the ß2 integrin family, is expressed on T cells, neutrophils, and macrophages and is thought to be the most important adhesion molecule for lymphocyte activation. It interacts with members of the immunoglobulin superfamily, the intercellular adhesion molecules: ICAM-1, -2, and -3. ICAM-1 and ICAM-2 are expressed on endodthelium and APCs, while ICAM-3 is expressed only on leukocytes. ICAM-1 is most homologous to neural cell adhesion molecule and myelin-associated glycoprotein. It is a 55 kDa glycoprotein that is heavily glycosylated to form 90 kDa to 115 kDa proteins. Its interactions with LFA-1 are necessary for CTL and NK mediated killing, T and B cell responses, and immune cell extravasation.
Synonyms: ICAM-1

Molekulargewicht: 90-115 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling