TAO Kinase 2 Antikörper (AA 352-550)

Produktnummer ABIN968499

Dieses Anti-TAO Kinase 2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TAO Kinase 2 in WB und IF. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für TAO Kinase 2 Antikörper (AA 352-550) (ABIN968499)

Target: TAO Kinase 2 (TAOK2)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TAO Kinase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 22-TAO1

Produktdetails anti-TAO Kinase 2 Antikörper

Bindungsspezifität: AA 352-550

Kreuzreaktivität: Maus, Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat TAO1 aa. 352-550

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-TAO Kinase 2 Antikörper (ABIN968499)

Hutchison, Berman, Cobb: "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 28625-32, (1998) (PubMed).

Details zu TAO Kinase 2

Target: TAO Kinase 2 (TAOK2)

Andere Bezeichnung: TAO1

Hintergrund: Mitogen activated protein kinases (MAPKs) are critical components of several signal transduction pathways that convert extracellular stimuli into cellular responses. Four groups of MAPKs (ERKs, JNKs, p38, and ERK5) have been identified in mammalian cells. MAPK pathways contain a 3-kinase cascade consisting of a MAPK, a MAP/ERK kinase (MEK), and a MEK kinase (MEKK). MEKK phosphorylation of MEKs leads to activation and subsequent MEK-mediated phosphorylation of both Thr and Tyr residues at the Thr-X-Tyr dual phosphorylation motif of MAPKs. TAO1 was isolated from a rat cDNA library using the sequence from yeast Ste20p kinase. Sequence analysis shows that TAO1 contains an N-terminal Ser/Thr protein kinase domain, an acidic domain, and two serine-rich domains. The catalytic domain of TAO1 is 40% identical to the p21-activated kinases, PAK1 and PAK2, and 33% identical to MEKK1. TAO1 expression is highest in brain, but it is also detected in heart and lung. TAO1 can activate MEK3, MEK4, and MEK6 from the stress-responsive MAPK pathway, but not MEK1 or 2 from the classical MAPK pathway. Thus, TAO1 may be an important MEKK in the p38-containing stress-responsive MAPK pathway.

Molekulargewicht: 116 kDa

Pathways: Cell-Cell Junction Organization