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STRAP Antikörper (AA 42-154)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch STRAP in WB und IF. Er zeigt eine Reaktivität gegenüber Human und Ratte und wurde in 1 Publikation erwähnt.
Produktnummer ABIN968485

Kurzübersicht für STRAP Antikörper (AA 42-154) (ABIN968485)

Target

Alle STRAP Antikörper anzeigen
STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Reaktivität

  • 46
  • 20
  • 11
  • 7
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte

Wirt

  • 47
Maus

Klonalität

  • 46
Monoklonal

Konjugat

  • 26
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser STRAP Antikörper ist unkonjugiert

Applikation

  • 39
  • 14
  • 13
  • 13
  • 10
  • 8
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)

Klon

22-STRAP
  • Bindungsspezifität

    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 42-154

    Kreuzreaktivität

    Ratte (Rattus), Human

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Mouse STRAP aa. 42-154

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN968545, ABIN967389

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20°C.
  • Datta, Chytil, Gorska, Moses: "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 273, Issue 52, pp. 34671-4, (1999) (PubMed).

  • Target

    STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

    Andere Bezeichnung

    STRAP

    Hintergrund

    The transforming growth factor beta (TGF-beta) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-beta receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-beta to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-betaI and TGF-betaII receptors and overexpression of STRAP leads to inhibition of TGF-beta-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-beta signal transduction pathways in a variety of tissues and species.

    Molekulargewicht

    39 kDa
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